Detailed information
Bioinformatically predicted
Overview
| Name | pilH | Type | Machinery gene |
| Locus tag | HT081_RS05840 | Genome accession | NZ_AP023073 |
| Coordinates | 1139574..1140239 (-) | Length | 221 a.a. |
| NCBI ID | WP_003701057.1 | Uniprot ID | - |
| Organism | Neisseria gonorrhoeae strain TUM15753 | ||
| Function | type IV pilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1087033..1150082 | 1139574..1140239 | within | 0 |
Gene organization within MGE regions
Location: 1087033..1150082
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HT081_RS05475 (TUM15753C_10650) | - | 1087033..1087686 (-) | 654 | WP_172763129.1 | IS1595 family transposase | - |
| HT081_RS05485 (TUM15753C_10670) | purM | 1088684..1089718 (-) | 1035 | WP_003698590.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| HT081_RS11710 (TUM15753C_10680) | - | 1089959..1090147 (+) | 189 | WP_003689039.1 | hypothetical protein | - |
| HT081_RS05490 | - | 1090407..1091396 (+) | 990 | WP_003689040.1 | site-specific integrase | - |
| HT081_RS05495 (TUM15753C_10700) | - | 1091738..1092217 (+) | 480 | WP_002241413.1 | DUF4760 domain-containing protein | - |
| HT081_RS05500 (TUM15753C_10710) | - | 1092277..1095321 (-) | 3045 | WP_172760435.1 | tape measure protein | - |
| HT081_RS05505 | - | 1095351..1095500 (-) | 150 | WP_003691402.1 | hypothetical protein | - |
| HT081_RS11715 (TUM15753C_10720) | - | 1095812..1095985 (-) | 174 | WP_003705498.1 | hypothetical protein | - |
| HT081_RS05510 (TUM15753C_10730) | - | 1095969..1096313 (-) | 345 | WP_003695464.1 | hypothetical protein | - |
| HT081_RS05515 (TUM15753C_10740) | - | 1096314..1096853 (-) | 540 | WP_050163081.1 | TIGR02594 family protein | - |
| HT081_RS12220 | - | 1096895..1097020 (-) | 126 | WP_255294325.1 | hypothetical protein | - |
| HT081_RS05520 (TUM15753C_10750) | - | 1097060..1097296 (+) | 237 | WP_003689049.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| HT081_RS05525 (TUM15753C_10760) | - | 1097296..1097643 (+) | 348 | WP_003689051.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| HT081_RS05530 (TUM15753C_10770) | - | 1097651..1097884 (+) | 234 | WP_003692884.1 | hypothetical protein | - |
| HT081_RS05535 (TUM15753C_10780) | - | 1098014..1098346 (-) | 333 | WP_003691408.1 | hypothetical protein | - |
| HT081_RS05540 (TUM15753C_10790) | - | 1098347..1098817 (-) | 471 | WP_003691410.1 | hypothetical protein | - |
| HT081_RS05545 (TUM15753C_10800) | - | 1098888..1099193 (-) | 306 | WP_003689058.1 | hypothetical protein | - |
| HT081_RS05550 (TUM15753C_10810) | - | 1099305..1103450 (-) | 4146 | WP_148048749.1 | phage tail protein | - |
| HT081_RS05555 (TUM15753C_10820) | - | 1103690..1103968 (+) | 279 | WP_003689062.1 | XRE family transcriptional regulator | - |
| HT081_RS05560 (TUM15753C_10830) | - | 1103996..1104427 (-) | 432 | WP_003689064.1 | NlpC/P60 family protein | - |
| HT081_RS05565 (TUM15753C_10840) | - | 1104429..1105283 (-) | 855 | WP_003698614.1 | DUF2163 domain-containing protein | - |
| HT081_RS05570 (TUM15753C_10850) | - | 1105280..1105879 (-) | 600 | WP_003692874.1 | DUF2460 domain-containing protein | - |
| HT081_RS05575 (TUM15753C_10860) | - | 1105879..1106145 (-) | 267 | WP_003689070.1 | hypothetical protein | - |
| HT081_RS05580 (TUM15753C_10870) | - | 1106157..1106486 (-) | 330 | WP_003692871.1 | hypothetical protein | - |
| HT081_RS05585 (TUM15753C_10880) | - | 1106547..1107317 (-) | 771 | WP_172760436.1 | hypothetical protein | - |
| HT081_RS05590 (TUM15753C_10890) | - | 1107343..1107771 (-) | 429 | WP_003689076.1 | hypothetical protein | - |
| HT081_RS05595 (TUM15753C_10900) | - | 1107768..1108250 (-) | 483 | WP_044271038.1 | HK97 gp10 family phage protein | - |
| HT081_RS05600 (TUM15753C_10910) | - | 1108250..1108780 (-) | 531 | WP_003689080.1 | head-tail connector protein | - |
| HT081_RS05605 (TUM15753C_10920) | - | 1108783..1109154 (-) | 372 | WP_148048747.1 | hypothetical protein | - |
| HT081_RS05610 (TUM15753C_10930) | - | 1109161..1110660 (-) | 1500 | WP_003691419.1 | hypothetical protein | - |
| HT081_RS05615 (TUM15753C_10940) | - | 1110702..1111859 (-) | 1158 | WP_010360058.1 | HK97 family phage prohead protease | - |
| HT081_RS05620 (TUM15753C_10950) | - | 1111927..1114074 (-) | 2148 | WP_003691423.1 | phage portal protein | - |
| HT081_RS05625 (TUM15753C_10960) | terL | 1114071..1115492 (-) | 1422 | WP_003689090.1 | phage terminase large subunit | - |
| HT081_RS05630 (TUM15753C_10970) | - | 1115554..1116003 (-) | 450 | WP_003695485.1 | hypothetical protein | - |
| HT081_RS05635 (TUM15753C_10980) | - | 1116296..1117219 (-) | 924 | WP_249931467.1 | type I restriction endonuclease | - |
| HT081_RS05640 (TUM15753C_10990) | - | 1117310..1117717 (-) | 408 | WP_003691430.1 | hypothetical protein | - |
| HT081_RS05645 (TUM15753C_11000) | - | 1117984..1118364 (-) | 381 | WP_017147222.1 | RusA family crossover junction endodeoxyribonuclease | - |
| HT081_RS12030 (TUM15753C_11010) | - | 1118355..1118636 (-) | 282 | WP_003689109.1 | hypothetical protein | - |
| HT081_RS05650 (TUM15753C_11020) | - | 1118664..1118813 (-) | 150 | WP_003689110.1 | hypothetical protein | - |
| HT081_RS05655 (TUM15753C_11030) | - | 1118990..1119484 (-) | 495 | WP_041421248.1 | DUF3310 domain-containing protein | - |
| HT081_RS05660 (TUM15753C_11040) | - | 1119498..1119728 (-) | 231 | WP_172762856.1 | hypothetical protein | - |
| HT081_RS05665 (TUM15753C_11050) | - | 1119798..1120580 (-) | 783 | WP_025456432.1 | ATP-binding protein | - |
| HT081_RS05670 (TUM15753C_11060) | - | 1120595..1121611 (-) | 1017 | WP_172760570.1 | helix-turn-helix domain-containing protein | - |
| HT081_RS05675 (TUM15753C_11070) | - | 1121608..1121835 (-) | 228 | WP_003691442.1 | helix-turn-helix domain-containing protein | - |
| HT081_RS05680 (TUM15753C_11080) | - | 1122008..1122196 (+) | 189 | WP_003698903.1 | hypothetical protein | - |
| HT081_RS05685 (TUM15753C_11090) | - | 1122173..1122328 (-) | 156 | WP_003691446.1 | hypothetical protein | - |
| HT081_RS05690 (TUM15753C_11100) | - | 1122408..1122623 (-) | 216 | WP_223169978.1 | helix-turn-helix transcriptional regulator | - |
| HT081_RS05695 (TUM15753C_11110) | - | 1122751..1123455 (+) | 705 | WP_003702453.1 | helix-turn-helix transcriptional regulator | - |
| HT081_RS05700 (TUM15753C_11120) | - | 1123615..1124154 (+) | 540 | WP_003695998.1 | type II toxin-antitoxin system antitoxin SocA domain-containing protein | - |
| HT081_RS05705 (TUM15753C_11130) | - | 1124155..1124514 (+) | 360 | WP_003691733.1 | hypothetical protein | - |
| HT081_RS05710 (TUM15753C_11140) | - | 1124531..1124749 (-) | 219 | WP_003691731.1 | hypothetical protein | - |
| HT081_RS05715 (TUM15753C_11150) | - | 1125233..1125433 (+) | 201 | WP_003692842.1 | hypothetical protein | - |
| HT081_RS05720 (TUM15753C_11160) | - | 1125466..1125942 (+) | 477 | WP_012504141.1 | hypothetical protein | - |
| HT081_RS05725 (TUM15753C_11170) | - | 1125939..1126226 (+) | 288 | WP_050155496.1 | hypothetical protein | - |
| HT081_RS05730 (TUM15753C_11180) | - | 1126367..1126699 (+) | 333 | WP_003687946.1 | hypothetical protein | - |
| HT081_RS05735 (TUM15753C_11200) | - | 1126852..1127130 (+) | 279 | WP_003691529.1 | NGO1622 family putative holin | - |
| HT081_RS05740 (TUM15753C_11210) | - | 1127127..1127288 (+) | 162 | WP_003693867.1 | hypothetical protein | - |
| HT081_RS05745 (TUM15753C_11220) | - | 1127357..1128043 (+) | 687 | WP_012503754.1 | phage replication initiation protein, NGO0469 family | - |
| HT081_RS05750 (TUM15753C_11230) | - | 1128183..1128365 (+) | 183 | WP_003691535.1 | hypothetical protein | - |
| HT081_RS05755 (TUM15753C_11240) | - | 1128362..1128853 (+) | 492 | WP_004464807.1 | siphovirus Gp157 family protein | - |
| HT081_RS05760 (TUM15753C_11250) | - | 1128905..1129120 (+) | 216 | WP_003691538.1 | hypothetical protein | - |
| HT081_RS12385 | - | 1129231..1129464 (+) | 234 | Protein_1122 | hypothetical protein | - |
| HT081_RS05770 (TUM15753C_11270) | - | 1129778..1130461 (+) | 684 | WP_003687929.1 | DUF2786 domain-containing protein | - |
| HT081_RS05775 (TUM15753C_11290) | - | 1130656..1130925 (+) | 270 | WP_003687928.1 | hypothetical protein | - |
| HT081_RS05780 (TUM15753C_11300) | - | 1131281..1132477 (-) | 1197 | WP_172760508.1 | integrase arm-type DNA-binding domain-containing protein | - |
| HT081_RS05795 (TUM15753C_11310) | yaaA | 1133008..1133787 (-) | 780 | WP_003694987.1 | peroxide stress protein YaaA | - |
| HT081_RS05800 (TUM15753C_11330) | dapC | 1133943..1135130 (-) | 1188 | WP_033910019.1 | succinyldiaminopimelate transaminase | - |
| HT081_RS05805 (TUM15753C_11340) | dut | 1135202..1135654 (-) | 453 | WP_172760504.1 | dUTP diphosphatase | - |
| HT081_RS05810 (TUM15753C_11350) | - | 1135820..1136529 (+) | 710 | Protein_1129 | AzlC family ABC transporter permease | - |
| HT081_RS05815 (TUM15753C_11360) | - | 1136526..1136834 (+) | 309 | WP_123771557.1 | AzlD family protein | - |
| HT081_RS05820 (TUM15753C_11370) | pilL | 1136904..1137377 (-) | 474 | WP_172760509.1 | PilX family type IV pilin | Machinery gene |
| HT081_RS05825 (TUM15753C_11380) | pilK | 1137379..1137990 (-) | 612 | WP_123771562.1 | PilX N-terminal domain-containing pilus assembly protein | Machinery gene |
| HT081_RS05830 (TUM15753C_11390) | pilJ | 1137969..1138937 (-) | 969 | WP_172760505.1 | PilW family protein | Machinery gene |
| HT081_RS05835 (TUM15753C_11400) | pilI | 1138934..1139542 (-) | 609 | WP_172760506.1 | type IV pilus modification protein PilV | Machinery gene |
| HT081_RS05840 (TUM15753C_11410) | pilH | 1139574..1140239 (-) | 666 | WP_003701057.1 | Tfp pilus assembly protein FimT/FimU | Machinery gene |
| HT081_RS05845 (TUM15753C_11420) | dnaB | 1140496..1141899 (-) | 1404 | WP_012503477.1 | replicative DNA helicase | - |
| HT081_RS05850 (TUM15753C_11430) | - | 1142062..1142643 (+) | 582 | WP_172760507.1 | superoxide dismutase | - |
| HT081_RS05855 (TUM15753C_11440) | - | 1142873..1143382 (-) | 510 | WP_003687909.1 | isoprenylcysteine carboxyl methyltransferase family protein | - |
| HT081_RS05860 (TUM15753C_11450) | - | 1143709..1144041 (-) | 333 | WP_003687908.1 | hypothetical protein | - |
| HT081_RS05865 (TUM15753C_11460) | cysT | 1144222..1145060 (+) | 839 | Protein_1140 | sulfate ABC transporter permease subunit CysT | - |
| HT081_RS05870 (TUM15753C_11470) | cysW | 1145249..1146109 (+) | 861 | WP_172760483.1 | sulfate ABC transporter permease subunit CysW | - |
| HT081_RS05875 (TUM15753C_11480) | - | 1146106..1147182 (+) | 1077 | WP_003687905.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
| HT081_RS05880 (TUM15753C_11490) | ilvA | 1147238..1148764 (-) | 1527 | WP_003690890.1 | threonine ammonia-lyase, biosynthetic | - |
| HT081_RS05885 (TUM15753C_11500) | - | 1148913..1150082 (+) | 1170 | WP_003690889.1 | D-alanyl-D-alanine carboxypeptidase family protein | - |
Sequence
Protein
Download Length: 221 a.a. Molecular weight: 24658.11 Da Isoelectric Point: 9.1564
>NTDB_id=81076 HT081_RS05840 WP_003701057.1 1139574..1140239(-) (pilH) [Neisseria gonorrhoeae strain TUM15753]
MCTRKQQGFTLTELLIVMAIAAIMATIALPNMSGWIASRRIASHAEQVANLLRFSRGEAVRLNLPVYICPTQVKKDGTGN
NQCDLGKKEQGMLAFGDKNDNKAYDGDAADVFLRSVVLNDDIKDKRIDYTFNHIAFGQTRPTADRVVWTFNQNGTFGYLP
DQNLKNNSKFVYSDGYIQIVLTDARAVSDADRKFRSAVVLIDSSGRVEVCRKNDTRAVCKH
MCTRKQQGFTLTELLIVMAIAAIMATIALPNMSGWIASRRIASHAEQVANLLRFSRGEAVRLNLPVYICPTQVKKDGTGN
NQCDLGKKEQGMLAFGDKNDNKAYDGDAADVFLRSVVLNDDIKDKRIDYTFNHIAFGQTRPTADRVVWTFNQNGTFGYLP
DQNLKNNSKFVYSDGYIQIVLTDARAVSDADRKFRSAVVLIDSSGRVEVCRKNDTRAVCKH
Nucleotide
Download Length: 666 bp
>NTDB_id=81076 HT081_RS05840 WP_003701057.1 1139574..1140239(-) (pilH) [Neisseria gonorrhoeae strain TUM15753]
ATGTGTACACGAAAACAACAAGGTTTCACGCTAACAGAGCTGCTCATCGTGATGGCCATTGCAGCCATTATGGCGACGAT
AGCCCTCCCCAATATGAGTGGGTGGATTGCATCACGCCGCATTGCCAGTCACGCGGAGCAGGTTGCCAACCTTTTGCGTT
TCTCCAGGGGCGAAGCCGTCCGGCTCAATCTCCCTGTCTATATCTGTCCTACCCAAGTTAAAAAAGACGGTACGGGCAAC
AACCAATGCGACCTCGGTAAGAAGGAACAGGGGATGTTGGCTTTCGGCGACAAAAACGACAATAAGGCATATGACGGCGA
TGCTGCGGATGTTTTTCTCCGCAGCGTGGTATTGAATGATGATATCAAGGATAAGCGGATTGATTACACTTTCAATCATA
TCGCTTTCGGTCAAACACGGCCGACTGCCGACCGTGTTGTTTGGACTTTTAACCAAAACGGGACATTCGGCTATTTGCCC
GATCAGAATCTCAAGAATAATTCCAAATTTGTTTATTCTGACGGTTATATCCAAATCGTGCTGACAGATGCGAGAGCAGT
TTCAGATGCCGATAGGAAATTCCGTTCGGCGGTGGTTTTGATTGACAGCAGCGGCAGGGTCGAAGTTTGTCGTAAAAACG
ATACGCGCGCCGTATGCAAACATTAA
ATGTGTACACGAAAACAACAAGGTTTCACGCTAACAGAGCTGCTCATCGTGATGGCCATTGCAGCCATTATGGCGACGAT
AGCCCTCCCCAATATGAGTGGGTGGATTGCATCACGCCGCATTGCCAGTCACGCGGAGCAGGTTGCCAACCTTTTGCGTT
TCTCCAGGGGCGAAGCCGTCCGGCTCAATCTCCCTGTCTATATCTGTCCTACCCAAGTTAAAAAAGACGGTACGGGCAAC
AACCAATGCGACCTCGGTAAGAAGGAACAGGGGATGTTGGCTTTCGGCGACAAAAACGACAATAAGGCATATGACGGCGA
TGCTGCGGATGTTTTTCTCCGCAGCGTGGTATTGAATGATGATATCAAGGATAAGCGGATTGATTACACTTTCAATCATA
TCGCTTTCGGTCAAACACGGCCGACTGCCGACCGTGTTGTTTGGACTTTTAACCAAAACGGGACATTCGGCTATTTGCCC
GATCAGAATCTCAAGAATAATTCCAAATTTGTTTATTCTGACGGTTATATCCAAATCGTGCTGACAGATGCGAGAGCAGT
TTCAGATGCCGATAGGAAATTCCGTTCGGCGGTGGTTTTGATTGACAGCAGCGGCAGGGTCGAAGTTTGTCGTAAAAACG
ATACGCGCGCCGTATGCAAACATTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pilH | Neisseria gonorrhoeae MS11 |
89.14 |
100 |
0.891 |