Detailed information NTG0798049

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: PY824_RS04195
• Genome accession: NZ_CP119172
• Coordinates: 757070..757936 (+)
• Length: 288 a.a.
• NCBI ID: WP_039670637.1
• Uniprot ID: A0A380K5F1
• Organism: Streptococcus macedonicus strain SGM CIP105683
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 752070..762936

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PY824_RS04165 (PY824_04165)	-	752345..753223 (+)	879	WP_093528137.1	F0F1 ATP synthase subunit gamma	-
PY824_RS04170 (PY824_04170)	atpD	753290..754696 (+)	1407	WP_039670634.1	F0F1 ATP synthase subunit beta	-
PY824_RS04175 (PY824_04175)	-	754709..755125 (+)	417	WP_093528140.1	F0F1 ATP synthase subunit epsilon	-
PY824_RS04180 (PY824_04180)	-	755190..755426 (+)	237	WP_014294304.1	DUF1146 family protein	-
PY824_RS04185 (PY824_04185)	murA	755489..756763 (+)	1275	WP_058621747.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
PY824_RS04190 (PY824_04190)	-	756766..756954 (+)	189	WP_009853912.1	DNA-directed RNA polymerase subunit beta	-
PY824_RS04195 (PY824_04195)	endA	757070..757936 (+)	867	WP_039670637.1	DNA/RNA non-specific endonuclease	Machinery gene
PY824_RS04200 (PY824_04200)	-	758005..758139 (+)	135	WP_257235419.1	hypothetical protein	-
PY824_RS04205 (PY824_04205)	-	758167..758412 (+)	246	Protein_759	GNAT family N-acetyltransferase	-
PY824_RS04210 (PY824_04210)	pheS	758862..759905 (+)	1044	WP_013642932.1	phenylalanine--tRNA ligase subunit alpha	-
PY824_RS04215 (PY824_04215)	-	759941..760465 (+)	525	WP_014294308.1	N-acetyltransferase	-

Sequence

Protein

• Length: 288 a.a.
• Molecular weight: 30873.94 Da
• Isoelectric Point: 5.6882

>NTDB_id=798049 PY824_RS04195 WP_039670637.1 757070..757936(+) (endA) [Streptococcus macedonicus strain SGM CIP105683]
MAKKSKLSKQTKSLMSLVILLVGIGAGWVTISDSNDPLNQVVSLITGDSSSEITSNQSSSDSATPTQSLAETVLTDSVKE
QLGENIEWNGAGAYIINDNQTSLNAKVSSQPYANNKTKTVQGQTVPTVANALLSKSTRQYKSREETGNGSTSWTPAGWHQ
VQDLSGTYSHAVDRGHLLGYALVGGLKGFDASTSNPDNVATQTAWANEANSESSTGQNYYESLVRKALDQKKRVRYRVTL
IYDGDNLLASGTHLEAKSSDGSLEFNVFVPNVQSGLTFDYYSGQVSVN

Nucleotide

• Length: 867 bp

>NTDB_id=798049 PY824_RS04195 WP_039670637.1 757070..757936(+) (endA) [Streptococcus macedonicus strain SGM CIP105683]
ATGGCAAAGAAATCAAAATTGTCTAAACAGACAAAATCCCTGATGTCTTTGGTGATTTTGTTAGTTGGTATTGGTGCTGG
TTGGGTGACGATATCAGATTCGAATGATCCGCTAAATCAAGTTGTTTCGTTAATTACTGGTGACTCCTCTTCTGAAATAA
CGTCAAATCAATCGAGTTCAGATTCGGCAACGCCAACACAATCTTTAGCAGAGACGGTATTAACAGATAGTGTCAAAGAG
CAGTTAGGAGAAAATATAGAATGGAATGGTGCGGGAGCCTATATTATCAATGATAATCAAACATCCCTAAATGCAAAAGT
TTCAAGTCAACCTTACGCCAACAACAAAACGAAAACGGTGCAAGGTCAGACTGTTCCAACGGTTGCTAATGCTTTGCTAA
GTAAGTCAACTCGTCAATACAAAAGTCGTGAGGAAACAGGAAATGGGTCGACCTCTTGGACGCCTGCGGGTTGGCATCAA
GTTCAAGACCTTTCAGGGACTTATAGCCATGCGGTAGACCGTGGGCATTTGCTTGGCTATGCTTTGGTTGGTGGTCTAAA
AGGCTTTGATGCGTCAACAAGCAACCCTGACAATGTGGCAACACAGACGGCTTGGGCGAACGAGGCAAATTCGGAAAGTT
CAACTGGTCAAAATTACTATGAATCCCTTGTCCGCAAAGCTCTTGACCAGAAAAAACGAGTTCGTTATCGTGTCACCTTG
ATTTATGACGGTGATAATCTCTTAGCAAGCGGAACGCATTTGGAAGCCAAATCATCTGACGGTAGTCTAGAATTTAACGT
CTTTGTTCCAAATGTGCAAAGCGGACTGACATTTGATTATTATTCAGGTCAAGTTAGTGTGAATTGA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (95-247)

3D structure

• AlphaFold DB: A0A380K5F1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	66.129	86.111	0.569
endA	Streptococcus pneumoniae D39	66.129	86.111	0.569
endA	Streptococcus pneumoniae R6	66.129	86.111	0.569
endA	Streptococcus pneumoniae TIGR4	66.129	86.111	0.569