Detailed information NTG0797107

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: PYW40_RS04795
• Genome accession: NZ_CP118979
• Coordinates: 997602..998648 (+)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain DSM 20263
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 992602..1003648

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PYW40_RS04770	map	993462..994214 (+)	753	WP_011275369.1	type I methionyl aminopeptidase	-
PYW40_RS04775	-	994339..995196 (-)	858	WP_011275370.1	SDR family oxidoreductase	-
PYW40_RS04780	-	995268..996280 (-)	1013	Protein_943	HoxN/HupN/NixA family nickel/cobalt transporter	-
PYW40_RS04785	-	996493..996879 (+)	387	WP_011275373.1	hypothetical protein	-
PYW40_RS04790	liaF	996904..997605 (+)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
PYW40_RS04795	vraS	997602..998648 (+)	1047	WP_011275375.1	sensor histidine kinase	Regulator
PYW40_RS04800	vraR	998638..999267 (+)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
PYW40_RS04805	-	999331..1000542 (-)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
PYW40_RS04810	-	1000739..1001023 (-)	285	WP_011275378.1	YtxH domain-containing protein	-
PYW40_RS04815	-	1001029..1001493 (-)	465	WP_011275379.1	low molecular weight protein-tyrosine-phosphatase	-
PYW40_RS04820	-	1001635..1001844 (+)	210	WP_011275380.1	DUF1128 domain-containing protein	-
PYW40_RS04825	-	1001858..1003105 (+)	1248	WP_011275381.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=797107 PYW40_RS04795 WP_011275375.1 997602..998648(+) (vraS) [Staphylococcus haemolyticus strain DSM 20263]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=797107 PYW40_RS04795 WP_011275375.1 997602..998648(+) (vraS) [Staphylococcus haemolyticus strain DSM 20263]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914