Detailed information NTG0078441

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: M2038_RS06230
• Genome accession: NZ_AP025693
• Coordinates: 1278253..1279026 (+)
• Length: 257 a.a.
• NCBI ID: WP_000055337.1
• Uniprot ID: P63843
• Organism: Staphylococcus aureus strain JICS127
• Function: repression of comK (predicted from homology) Competence regulation

Genomic Context

Location: 1273253..1284026

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M2038_RS06210 (JICS127ACC_1196)	trmFO	1273597..1274904 (+)	1308	WP_000195254.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-
M2038_RS06215 (JICS127ACC_1197)	xerC	1275321..1276217 (+)	897	WP_001015597.1	tyrosine recombinase XerC	-
M2038_RS06220 (JICS127ACC_1198)	hslV	1276214..1276759 (+)	546	WP_000072681.1	ATP-dependent protease subunit HslV	-
M2038_RS06225 (JICS127ACC_1199)	hslU	1276825..1278228 (+)	1404	WP_000379054.1	ATP-dependent protease ATPase subunit HslU	-
M2038_RS06230 (JICS127ACC_1200)	codY	1278253..1279026 (+)	774	WP_000055337.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
M2038_RS06235	-	1279077..1279169 (+)	93	WP_001790530.1	hypothetical protein	-
M2038_RS06240 (JICS127ACC_1201)	rpsB	1279368..1280135 (+)	768	WP_000268484.1	30S ribosomal protein S2	-
M2038_RS06245 (JICS127ACC_1202)	-	1280169..1280282 (+)	114	WP_001789890.1	hypothetical protein	-
M2038_RS06250 (JICS127ACC_1203)	tsf	1280317..1281198 (+)	882	WP_000201387.1	translation elongation factor Ts	-
M2038_RS06255 (JICS127ACC_1204)	pyrH	1281335..1282057 (+)	723	WP_000057330.1	UMP kinase	-
M2038_RS06260 (JICS127ACC_1205)	frr	1282076..1282630 (+)	555	WP_001280006.1	ribosome recycling factor	-
M2038_RS06265 (JICS127ACC_1206)	-	1283003..1283773 (+)	771	WP_000473705.1	isoprenyl transferase	-

Sequence

Protein

• Length: 257 a.a.
• Molecular weight: 28755.13 Da
• Isoelectric Point: 6.0680

>NTDB_id=78441 M2038_RS06230 WP_000055337.1 1278253..1279026(+) (codY) [Staphylococcus aureus strain JICS127]
MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLM
EVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHS
EVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSLGMKGT
FIKVKKEKFLDELEKSK

Nucleotide

• Length: 774 bp

>NTDB_id=78441 M2038_RS06230 WP_000055337.1 1278253..1279026(+) (codY) [Staphylococcus aureus strain JICS127]
ATGAGCTTATTATCTAAAACGAGAGAGTTAAACACGTTACTTCAAAAACACAAAGGTATTGCGGTTGATTTTAAAGATGT
AGCACAAACGATTAGTAGCGTAACTGTAACAAATGTATTTATTGTATCGCGTCGAGGTAAAATTTTAGGATCGAGTCTAA
ATGAATTATTAAAAAGTCAAAGAATTATTCAAATGTTGGAAGAAAGACATATTCCAAGTGAATATACAGAACGATTAATG
GAAGTTAAACAAACAGAATCAAATATTGATATCGACAATGTATTAACAGTATTCCCACCTGAAAACAGAGAATTATTCAT
AGATAGTCGTACAACTATCTTCCCAATTTTAGGTGGAGGGGAAAGATTAGGTACATTAGTACTTGGTCGAGTACATGATG
ATTTTAATGAAAATGATTTGGTACTAGGTGAATATGCTGCTACAGTTATTGGTATGGAAATCTTACGTGAGAAGCATAGT
GAAGTAGAAAAAGAAGCGCGCGATAAAGCTGCTATTACAATGGCAATTAATTCATTATCTTATTCTGAAAAAGAAGCGAT
TGAACATATCTTTGAAGAACTTGGCGGTACGGAAGGCCTATTAATCGCATCAAAAGTTGCAGATAGAGTTGGTATTACTA
GATCTGTAATTGTAAATGCACTACGTAAATTAGAAAGTGCTGGTGTAATTGAATCACGTTCTTTAGGAATGAAAGGTACT
TTCATTAAAGTTAAAAAAGAAAAATTCTTAGATGAATTAGAAAAAAGTAAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (2-178)

• CodY helix-turn-helix domain (HTH_CodY) (198-255)

3D structure

• AlphaFold DB: P63843

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Bacillus subtilis subsp. subtilis str. 168	64.202	100	0.642
codY	Lactococcus lactis subsp. lactis strain DGCC12653	42.802	100	0.428