Detailed information NTG0074519

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SAGCMC97051_RS00405
• Genome accession: NZ_AP020310
• Coordinates: 64071..64982 (+)
• Length: 303 a.a.
• NCBI ID: WP_000912100.1
• Uniprot ID: A0A0E1EEL0
• Organism: Streptococcus agalactiae strain GCMC97051
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 59071..69982

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAGCMC97051_RS00385 (SAGCMC97051_00420)	purE	59585..60073 (+)	489	WP_001182532.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SAGCMC97051_RS00390 (SAGCMC97051_00430)	purK	60060..61151 (+)	1092	WP_001084004.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SAGCMC97051_RS00395 (SAGCMC97051_00440)	-	61205..62596 (+)	1392	WP_001079802.1	hypothetical protein	-
SAGCMC97051_RS00400 (SAGCMC97051_00450)	purB	62621..63919 (+)	1299	WP_000572887.1	adenylosuccinate lyase	-
SAGCMC97051_RS00405 (SAGCMC97051_00460)	comR	64071..64982 (+)	912	WP_000912100.1	helix-turn-helix domain-containing protein	Regulator
SAGCMC97051_RS00410 (SAGCMC97051_00470)	ruvB	65279..66277 (+)	999	WP_000196634.1	Holliday junction branch migration DNA helicase RuvB	-
SAGCMC97051_RS00415 (SAGCMC97051_00480)	-	66429..66866 (+)	438	WP_000754813.1	low molecular weight protein-tyrosine-phosphatase	-
SAGCMC97051_RS00420 (SAGCMC97051_00490)	-	66873..67253 (+)	381	WP_000787700.1	membrane protein	-
SAGCMC97051_RS00425 (SAGCMC97051_00500)	-	67250..69028 (+)	1779	WP_001220909.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35654.11 Da
• Isoelectric Point: 5.6370

>NTDB_id=74519 SAGCMC97051_RS00405 WP_000912100.1 64071..64982(+) (comR) [Streptococcus agalactiae strain GCMC97051]
MLKHFGSKVRNLRVTRNITREDFCGDETELSVRQLARIESGQSIPNLTKAHYIAKQLNVKLDILTGGESLELPKRYKELK
YLILRIPTYADAERLKLRECQFDHIFEEFYDNLPEDECLAIDSLQAKFEVYQTGDINFGVEVLCECFDKVKYKEKYTLND
LIIIDLFLTCAVVSKFNNRAFTKEVFQTICKTLISQNHKLTAEDLFWFNHVLLNCVFVGLCLNSEECLAEMLEVSRQTMV
STHDFHKMPLYFMYQWKYFITIDNDIKSAENAYQQSIMFSKMIDDKHLIKKLELEWQEDITGH

Nucleotide

• Length: 912 bp

>NTDB_id=74519 SAGCMC97051_RS00405 WP_000912100.1 64071..64982(+) (comR) [Streptococcus agalactiae strain GCMC97051]
ATGTTAAAACATTTTGGTAGTAAAGTAAGAAATTTGAGAGTAACTAGAAATATTACTCGCGAAGATTTTTGTGGTGATGA
AACTGAGTTATCTGTAAGACAATTAGCTAGGATTGAAAGTGGACAGTCAATTCCAAACTTGACTAAAGCTCACTACATAG
CTAAACAATTGAATGTAAAATTGGATATTTTAACAGGAGGAGAGAGCTTAGAATTACCTAAACGGTATAAAGAGTTGAAG
TATTTGATTTTAAGAATTCCAACTTATGCAGATGCTGAACGATTAAAATTAAGAGAATGTCAGTTTGATCATATTTTCGA
AGAATTCTATGATAATCTTCCAGAAGACGAGTGCTTAGCAATTGACAGTTTACAAGCTAAATTTGAAGTCTATCAAACAG
GAGACATTAATTTTGGTGTGGAGGTTTTATGCGAATGCTTTGATAAAGTAAAATATAAAGAAAAATATACTCTTAATGAT
TTGATTATCATAGATTTGTTTTTAACTTGTGCAGTTGTATCTAAATTTAACAATAGAGCATTTACTAAAGAAGTATTTCA
AACTATATGTAAAACTTTGATAAGTCAGAACCACAAACTTACAGCAGAAGATTTGTTTTGGTTTAATCATGTACTCCTGA
ATTGTGTATTTGTTGGACTTTGTTTAAATAGTGAAGAGTGTCTTGCAGAAATGTTAGAAGTTAGCCGACAAACGATGGTG
TCAACACATGATTTTCATAAAATGCCTTTATATTTTATGTACCAATGGAAATACTTCATTACAATTGACAATGATATAAA
GTCTGCAGAAAATGCTTACCAACAATCAATTATGTTTTCAAAAATGATTGATGACAAGCATCTAATTAAAAAATTAGAAT
TGGAGTGGCAAGAAGATATAACAGGACATTGA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (10-64)

3D structure

• AlphaFold DB: A0A0E1EEL0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	52.667	99.01	0.521
comR	Streptococcus mutans UA159	44.816	98.68	0.442
comR	Streptococcus pyogenes MGAS8232	42.904	100	0.429
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	44.33	96.04	0.426