Detailed information NTG0712872

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: PND17_RS02025
• Genome accession: NZ_CP116772
• Coordinates: 380951..381736 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain strain TSGB 4141
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 375951..386736

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PND17_RS01990 (PND17_01990)	gatC	376016..376318 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
PND17_RS01995 (PND17_01995)	-	376458..376712 (-)	255	WP_041827766.1	glycosyl transferase	-
PND17_RS02000 (PND17_02000)	-	376725..376922 (-)	198	WP_231108739.1	glycosyltransferase	-
PND17_RS02005 (PND17_02005)	-	377250..378691 (-)	1442	Protein_390	6-phospho-beta-glucosidase	-
PND17_RS02010 (PND17_02010)	msrA	378844..379353 (-)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
PND17_RS02015 (PND17_02015)	-	379365..380213 (-)	849	WP_271295926.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
PND17_RS02020 (PND17_02020)	-	380337..380888 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
PND17_RS02025 (PND17_02025)	codY	380951..381736 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
PND17_RS02030 (PND17_02030)	-	381996..383210 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
PND17_RS02035 (PND17_02035)	-	383565..384017 (+)	453	WP_002946987.1	universal stress protein	-
PND17_RS02040 (PND17_02040)	-	384194..384768 (+)	575	Protein_397	IS30 family transposase	-
PND17_RS02045 (PND17_02045)	-	384840..385448 (-)	609	WP_271298148.1	hypothetical protein	-
PND17_RS02050 (PND17_02050)	pflA	385660..386460 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=712872 PND17_RS02025 WP_002951720.1 380951..381736(-) (codY) [Streptococcus thermophilus strain strain TSGB 4141]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=712872 PND17_RS02025 WP_002951720.1 380951..381736(-) (codY) [Streptococcus thermophilus strain strain TSGB 4141]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTAGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGATAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502