Detailed information NTG0700131

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LPT17_RS00450
• Genome accession: NZ_CP099502
• Coordinates: 81139..82182 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JL42
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76139..87182

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LPT17_RS00420 (LPT17_00420)	-	76754..76864 (+)	111	WP_014937049.1	hypothetical protein	-
LPT17_RS00425 (LPT17_00425)	-	76893..77306 (+)	414	WP_025174370.1	hypothetical protein	-
LPT17_RS00430 (LPT17_00430)	-	77495..78481 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
LPT17_RS00435 (LPT17_00435)	map	79065..79823 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
LPT17_RS00440 (LPT17_00440)	-	80040..80426 (+)	387	WP_001110182.1	hypothetical protein	-
LPT17_RS00445 (LPT17_00445)	liaF	80441..81142 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LPT17_RS00450 (LPT17_00450)	vraS	81139..82182 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LPT17_RS00455 (LPT17_00455)	vraR	82172..82801 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LPT17_RS00460 (LPT17_00460)	-	82914..84131 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
LPT17_RS00465 (LPT17_00465)	-	84409..84684 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LPT17_RS00470 (LPT17_00470)	-	84691..85155 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LPT17_RS00475 (LPT17_00475)	-	85302..85502 (+)	201	WP_000180460.1	DUF1128 family protein	-
LPT17_RS00480 (LPT17_00480)	-	85505..86761 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=700131 LPT17_RS00450 WP_001017131.1 81139..82182(+) (vraS) [Staphylococcus aureus strain JL42]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=700131 LPT17_RS00450 WP_001017131.1 81139..82182(+) (vraS) [Staphylococcus aureus strain JL42]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1