Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | MZK36_RS08970 | Genome accession | NZ_CP096809 |
| Coordinates | 1756271..1756891 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain SP007 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1744726..1788645 | 1756271..1756891 | within | 0 |
Gene organization within MGE regions
Location: 1744726..1788645
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MZK36_RS08900 (MZK36_08840) | - | 1745023..1745574 (-) | 552 | WP_001111247.1 | hypothetical protein | - |
| MZK36_RS08905 (MZK36_08845) | - | 1745564..1745761 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| MZK36_RS08910 (MZK36_08850) | - | 1745765..1746559 (-) | 795 | WP_001101215.1 | hypothetical protein | - |
| MZK36_RS08915 (MZK36_08855) | - | 1746967..1747392 (-) | 426 | WP_000204068.1 | hypothetical protein | - |
| MZK36_RS08920 (MZK36_08860) | - | 1747521..1747880 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| MZK36_RS08925 (MZK36_08865) | - | 1747926..1748132 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| MZK36_RS08930 (MZK36_08870) | - | 1748119..1748280 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| MZK36_RS08935 (MZK36_08875) | lytA | 1748639..1749595 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| MZK36_RS08940 (MZK36_08880) | - | 1749971..1751341 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| MZK36_RS08945 (MZK36_08885) | recA | 1751648..1752814 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| MZK36_RS08950 (MZK36_08890) | cinA | 1752869..1754125 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| MZK36_RS08955 (MZK36_08895) | brpA | 1754210..1755226 (-) | 1017 | WP_000239278.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| MZK36_RS08960 (MZK36_08900) | - | 1755234..1755752 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| MZK36_RS08965 (MZK36_08905) | tsaE | 1755742..1756185 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| MZK36_RS08970 (MZK36_08910) | comM | 1756271..1756891 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| MZK36_RS08975 (MZK36_08915) | - | 1757197..1758060 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| MZK36_RS08980 | - | 1758252..1758422 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| MZK36_RS08985 (MZK36_08920) | - | 1758824..1759138 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| MZK36_RS08990 (MZK36_08925) | - | 1759154..1759540 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| MZK36_RS08995 (MZK36_08930) | - | 1759569..1760954 (+) | 1386 | WP_000813494.1 | FtsK/SpoIIIE domain-containing protein | - |
| MZK36_RS09000 (MZK36_08935) | - | 1760957..1761109 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| MZK36_RS09005 (MZK36_08940) | mobT | 1761132..1762394 (+) | 1263 | WP_001814870.1 | MobT family relaxase | - |
| MZK36_RS09010 (MZK36_08945) | - | 1762339..1762551 (+) | 213 | WP_029645760.1 | peptide-binding protein | - |
| MZK36_RS09015 (MZK36_08950) | - | 1762600..1762683 (+) | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| MZK36_RS09020 (MZK36_08955) | erm(B) | 1762808..1763545 (+) | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| MZK36_RS09025 (MZK36_08960) | - | 1763802..1765049 (-) | 1248 | WP_000019067.1 | ISL3 family transposase | - |
| MZK36_RS09030 (MZK36_08965) | - | 1765229..1765450 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| MZK36_RS09035 (MZK36_08970) | - | 1765567..1766064 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| MZK36_RS09040 (MZK36_08975) | - | 1766153..1766545 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| MZK36_RS09045 (MZK36_08980) | - | 1766529..1768976 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| MZK36_RS09050 (MZK36_08985) | - | 1768979..1771156 (+) | 2178 | WP_001814875.1 | CD3337/EF1877 family mobilome membrane protein | - |
| MZK36_RS09055 (MZK36_08990) | - | 1771153..1772154 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| MZK36_RS09060 (MZK36_08995) | - | 1772151..1773083 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| MZK36_RS10890 | - | 1773397..1773444 (+) | 48 | Protein_1778 | hypothetical protein | - |
| MZK36_RS09070 (MZK36_09005) | tet(M) | 1773460..1775379 (+) | 1920 | WP_219574192.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| MZK36_RS09075 (MZK36_09010) | - | 1775743..1775988 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| MZK36_RS09080 (MZK36_09015) | - | 1775985..1776320 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| MZK36_RS09085 (MZK36_09020) | - | 1776333..1776701 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| MZK36_RS09090 (MZK36_09025) | - | 1776688..1776987 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| MZK36_RS09095 (MZK36_09030) | msr(D) | 1777105..1778568 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| MZK36_RS09100 (MZK36_09035) | mef(A) | 1778688..1779905 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| MZK36_RS09105 (MZK36_09040) | - | 1780291..1780461 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| MZK36_RS09110 (MZK36_09045) | - | 1780983..1781174 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| MZK36_RS09115 (MZK36_09050) | - | 1781234..1781587 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| MZK36_RS09120 (MZK36_09055) | - | 1782092..1782514 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| MZK36_RS09125 (MZK36_09060) | - | 1782511..1782741 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| MZK36_RS09130 (MZK36_09065) | - | 1782967..1783218 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| MZK36_RS09135 (MZK36_09070) | - | 1783202..1783405 (+) | 204 | WP_000814511.1 | excisionase | - |
| MZK36_RS09140 (MZK36_09075) | - | 1783487..1784704 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| MZK36_RS09145 (MZK36_09080) | - | 1785595..1787610 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| MZK36_RS09150 (MZK36_09085) | - | 1787612..1788244 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=684240 MZK36_RS08970 WP_000839909.1 1756271..1756891(-) (comM) [Streptococcus pneumoniae strain SP007]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=684240 MZK36_RS08970 WP_000839909.1 1756271..1756891(-) (comM) [Streptococcus pneumoniae strain SP007]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |