Detailed information NTG0681532

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M1F50_RS09785
• Genome accession: NZ_CP096528
• Coordinates: 1986428..1987471 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM_M084986
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1981428..1992471

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1F50_RS09755 (M1F50_09735)	-	1981849..1983105 (-)	1257	WP_074347694.1	aminopeptidase	-
M1F50_RS09760 (M1F50_09740)	-	1983108..1983308 (-)	201	WP_000180460.1	DUF1128 family protein	-
M1F50_RS09765 (M1F50_09745)	-	1983455..1983919 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M1F50_RS09770 (M1F50_09750)	-	1983926..1984201 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M1F50_RS09775 (M1F50_09755)	-	1984479..1985696 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
M1F50_RS09780 (M1F50_09760)	vraR	1985809..1986438 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
M1F50_RS09785 (M1F50_09765)	vraS	1986428..1987471 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M1F50_RS09790 (M1F50_09770)	liaF	1987468..1988169 (-)	702	WP_000149063.1	cell wall-active antibiotics response protein LiaF	-
M1F50_RS09795 (M1F50_09775)	-	1988184..1988570 (-)	387	WP_001110182.1	hypothetical protein	-
M1F50_RS09800 (M1F50_09780)	map	1988787..1989545 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
M1F50_RS09805 (M1F50_09785)	-	1990129..1991115 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
M1F50_RS09810 (M1F50_09790)	-	1991304..1991717 (-)	414	WP_025174370.1	hypothetical protein	-
M1F50_RS09815 (M1F50_09795)	-	1991746..1991856 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=681532 M1F50_RS09785 WP_001017131.1 1986428..1987471(-) (vraS) [Staphylococcus aureus strain RIVM_M084986]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=681532 M1F50_RS09785 WP_001017131.1 1986428..1987471(-) (vraS) [Staphylococcus aureus strain RIVM_M084986]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1