Detailed information NTG0672812

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA85_RS09900
• Genome accession: NZ_CP094799
• Coordinates: 2001817..2002860 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6159
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1996817..2007860

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA85_RS09870 (MUA85_09850)	-	1997236..1998492 (-)	1257	WP_250425878.1	aminopeptidase	-
MUA85_RS09875 (MUA85_09855)	-	1998495..1998695 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA85_RS09880 (MUA85_09860)	-	1998842..1999306 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA85_RS09885 (MUA85_09865)	-	1999313..1999588 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA85_RS09890 (MUA85_09870)	-	1999868..2001085 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA85_RS09895 (MUA85_09875)	vraR	2001198..2001827 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
MUA85_RS09900 (MUA85_09880)	vraS	2001817..2002860 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA85_RS09905 (MUA85_09885)	liaF	2002857..2003558 (-)	702	WP_000149070.1	cell wall-active antibiotics response protein LiaF	-
MUA85_RS09910 (MUA85_09890)	-	2003573..2003959 (-)	387	WP_001110179.1	hypothetical protein	-
MUA85_RS09915 (MUA85_09895)	map	2004176..2004934 (-)	759	WP_111014375.1	type I methionyl aminopeptidase	-
MUA85_RS09920 (MUA85_09900)	-	2005461..2006447 (+)	987	WP_000999713.1	FUSC family protein	-
MUA85_RS09925 (MUA85_09905)	-	2006636..2007049 (-)	414	WP_025174666.1	hypothetical protein	-
MUA85_RS09930 (MUA85_09910)	-	2007078..2007188 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672812 MUA85_RS09900 WP_001017131.1 2001817..2002860(-) (vraS) [Staphylococcus aureus strain IVB6159]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672812 MUA85_RS09900 WP_001017131.1 2001817..2002860(-) (vraS) [Staphylococcus aureus strain IVB6159]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1