Detailed information NTG0672095

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA83_RS09975
• Genome accession: NZ_CP094763
• Coordinates: 2020998..2022041 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6221
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2015998..2027041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA83_RS09945 (MUA83_09940)	-	2016419..2017675 (-)	1257	WP_001793428.1	aminopeptidase	-
MUA83_RS09950 (MUA83_09945)	-	2017678..2017878 (-)	201	WP_000180460.1	DUF1128 family protein	-
MUA83_RS09955 (MUA83_09950)	-	2018025..2018489 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA83_RS09960 (MUA83_09955)	-	2018496..2018771 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA83_RS09965 (MUA83_09960)	-	2019049..2020266 (+)	1218	WP_045158466.1	YihY/virulence factor BrkB family protein	-
MUA83_RS09970 (MUA83_09965)	vraR	2020379..2021008 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
MUA83_RS09975 (MUA83_09970)	vraS	2020998..2022041 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA83_RS09980 (MUA83_09975)	liaF	2022038..2022739 (-)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
MUA83_RS09985 (MUA83_09980)	-	2022754..2023140 (-)	387	WP_001110179.1	hypothetical protein	-
MUA83_RS09990 (MUA83_09985)	map	2023357..2024115 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA83_RS09995 (MUA83_09990)	-	2024642..2025628 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
MUA83_RS10000 (MUA83_09995)	-	2025817..2026230 (-)	414	WP_252550078.1	hypothetical protein	-
MUA83_RS10005 (MUA83_10000)	-	2026259..2026371 (-)	113	Protein_1934	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672095 MUA83_RS09975 WP_001017131.1 2020998..2022041(-) (vraS) [Staphylococcus aureus strain IVB6221]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672095 MUA83_RS09975 WP_001017131.1 2020998..2022041(-) (vraS) [Staphylococcus aureus strain IVB6221]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1