Detailed information NTG0647059

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KB233_RS04220
• Genome accession: NZ_CP090998
• Coordinates: 910560..911606 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain BC1191
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 905560..916606

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KB233_RS04195 (KB233_04195)	isaB	906702..907238 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
KB233_RS04200 (KB233_04200)	-	907389..908374 (-)	986	Protein_825	FUSC family protein	-
KB233_RS04205 (KB233_04205)	map	908548..909303 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
KB233_RS04210 (KB233_04210)	-	909461..909847 (+)	387	WP_001830382.1	hypothetical protein	-
KB233_RS04215 (KB233_04215)	liaF	909862..910563 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
KB233_RS04220 (KB233_04220)	vraS	910560..911606 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KB233_RS04225 (KB233_04225)	vraR	911596..912225 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KB233_RS04230 (KB233_04230)	-	912282..913460 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KB233_RS04235 (KB233_04235)	-	913867..914151 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KB233_RS04240 (KB233_04240)	-	914159..914623 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KB233_RS04245 (KB233_04245)	-	914764..914979 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KB233_RS04250 (KB233_04250)	-	914981..916222 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=647059 KB233_RS04220 WP_001830374.1 910560..911606(+) (vraS) [Staphylococcus epidermidis strain BC1191]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=647059 KB233_RS04220 WP_001830374.1 910560..911606(+) (vraS) [Staphylococcus epidermidis strain BC1191]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92