Detailed information NTG0611085

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: NN994_RS07555
• Genome accession: NZ_CP101646
• Coordinates: 1450202..1450987 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain UCCSt95
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1445202..1455987

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NN994_RS07520 (NN994_07525)	gatC	1445264..1445566 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
NN994_RS07525 (NN994_07530)	-	1445706..1445960 (-)	255	WP_024010053.1	glycosyl transferase	-
NN994_RS07530 (NN994_07535)	-	1445973..1446170 (-)	198	WP_014608644.1	glycosyltransferase	-
NN994_RS07535 (NN994_07540)	-	1446498..1447942 (-)	1445	Protein_1427	6-phospho-beta-glucosidase	-
NN994_RS07540 (NN994_07545)	msrA	1448095..1448604 (-)	510	WP_064355822.1	peptide-methionine (S)-S-oxide reductase MsrA	-
NN994_RS07545 (NN994_07550)	-	1448616..1449464 (-)	849	WP_064355823.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
NN994_RS07550 (NN994_07555)	-	1449588..1450139 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
NN994_RS07555 (NN994_07560)	codY	1450202..1450987 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
NN994_RS07560 (NN994_07565)	-	1451247..1452461 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
NN994_RS07565 (NN994_07570)	-	1452816..1453268 (+)	453	WP_002946987.1	universal stress protein	-
NN994_RS07570 (NN994_07575)	-	1453448..1454019 (+)	572	Protein_1434	IS30 family transposase	-
NN994_RS07575 (NN994_07580)	-	1454091..1454264 (-)	174	WP_014621904.1	hypothetical protein	-
NN994_RS07580 (NN994_07585)	-	1454325..1454699 (-)	375	WP_011681547.1	membrane protein	-
NN994_RS07585 (NN994_07590)	pflA	1454911..1455711 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=611085 NN994_RS07555 WP_002951720.1 1450202..1450987(-) (codY) [Streptococcus thermophilus strain UCCSt95]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=611085 NN994_RS07555 WP_002951720.1 1450202..1450987(-) (codY) [Streptococcus thermophilus strain UCCSt95]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502