Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   NBY18_RS03770 Genome accession   NZ_CP098206
Coordinates   770095..770754 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain Z0117EC0054     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 765095..775754
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NBY18_RS03740 (NBY18_03740) ygiN 765996..766310 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  NBY18_RS03745 (NBY18_03745) mdaB 766341..766922 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  NBY18_RS03750 (NBY18_03750) - 767172..767651 (+) 480 WP_000069056.1 Hcp family type VI secretion system effector -
  NBY18_RS03755 (NBY18_03755) - 767654..768364 (+) 711 WP_000834021.1 hypothetical protein -
  NBY18_RS03760 (NBY18_03760) ygiZ 768371..768703 (+) 333 WP_000914696.1 DUF2645 family protein -
  NBY18_RS03765 (NBY18_03765) qseC 768749..770098 (-) 1350 WP_000673382.1 quorum sensing histidine kinase QseC -
  NBY18_RS03770 (NBY18_03770) ciaR 770095..770754 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  NBY18_RS03775 (NBY18_03775) ygiW 770906..771298 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  NBY18_RS03780 (NBY18_03780) ygiV 771351..771833 (+) 483 WP_000183493.1 GyrI-like domain-containing protein -
  NBY18_RS03785 (NBY18_03785) ygiS 771942..773549 (+) 1608 WP_001350728.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=597980 NBY18_RS03770 WP_001221493.1 770095..770754(-) (ciaR) [Escherichia coli strain Z0117EC0054]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=597980 NBY18_RS03770 WP_001221493.1 770095..770754(-) (ciaR) [Escherichia coli strain Z0117EC0054]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365