Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   SPN034183_RS04670 Genome accession   NC_021028
Coordinates   868630..870870 (+) Length   746 a.a.
NCBI ID   WP_000942414.1    Uniprot ID   A0A4J1ZQU0
Organism   Streptococcus pneumoniae SPN034183     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 863630..875870
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN034183_RS04630 (SPN034183_08500) - 863781..864749 (+) 969 Protein_889 PhoH family protein -
  SPN034183_RS04635 (SPN034183_08510) - 864942..865442 (+) 501 WP_000566982.1 GNAT family N-acetyltransferase -
  SPN034183_RS04640 (SPN034183_08520) - 865445..865770 (+) 326 Protein_891 TfoX/Sxy family protein -
  SPN034183_RS13070 (SPN034183_08530) ald 866071..867182 (-) 1112 Protein_892 alanine dehydrogenase -
  SPN034183_RS04660 (SPN034183_08540) - 867359..867928 (+) 570 WP_000443774.1 GNAT family N-acetyltransferase -
  SPN034183_RS04665 (SPN034183_08550) comEA/celA/cilE 867996..868646 (+) 651 WP_000387335.1 helix-hairpin-helix domain-containing protein Machinery gene
  SPN034183_RS04670 (SPN034183_08560) comEC/celB 868630..870870 (+) 2241 WP_000942414.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  SPN034183_RS04675 - 871049..871237 (+) 189 WP_001809102.1 hypothetical protein -
  SPN034183_RS04680 (SPN034183_08570) - 871269..871856 (+) 588 WP_000933542.1 ABC transporter ATP-binding protein -
  SPN034183_RS04685 (SPN034183_08580) - 871860..873035 (+) 1176 WP_000655957.1 ABC transporter permease -
  SPN034183_RS04690 (SPN034183_08590) infC 873356..873886 (+) 531 WP_000848180.1 translation initiation factor IF-3 -
  SPN034183_RS04695 (SPN034183_08600) rpmI 873919..874119 (+) 201 WP_001125943.1 50S ribosomal protein L35 -
  SPN034183_RS04700 (SPN034183_08610) rplT 874171..874530 (+) 360 WP_000124836.1 50S ribosomal protein L20 -
  SPN034183_RS04705 (SPN034183_08620) - 874588..874968 (+) 381 WP_000157157.1 VOC family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84540.03 Da        Isoelectric Point: 9.6773

>NTDB_id=58169 SPN034183_RS04670 WP_000942414.1 868630..870870(+) (comEC/celB) [Streptococcus pneumoniae SPN034183]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSTSYLALLGFVFLLVCLFFQFPWKSASKVLVICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFFTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGSKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=58169 SPN034183_RS04670 WP_000942414.1 868630..870870(+) (comEC/celB) [Streptococcus pneumoniae SPN034183]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTGTTACTTTGGCTTTACTACGCCATTTT
TTCAACATCCTATCTTGCTTTGTTGGGATTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTA
GCAAAGTTCTAGTGATTTGTGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTTACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCTCTAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Domain of unknown function (DUF4131) (DUF4131)

(31-176)

Competence protein (Competence)

(216-458)

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-697)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1ZQU0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

97.721

100

0.977
  comEC/celB Streptococcus pneumoniae Rx1

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae D39

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae R6

96.649

100

0.966
  comEC/celB Streptococcus mitis SK321

92.359

100

0.924
  comEC/celB Streptococcus mitis NCTC 12261

92.081

99.866

0.92
  comEC Lactococcus lactis subsp. cremoris KW2

44.534

99.33

0.442

Multiple sequence alignment