Detailed information NTG0057862

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SPN032672_RS04505
• Genome accession: NC_021003
• Coordinates: 844833..845585 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae SPN032672
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 839833..850585

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN032672_RS04475	spo0J	840424..841182 (-)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator
SPN032672_RS04480	htrA	841240..842421 (-)	1182	WP_000681598.1	S1C family serine protease	Regulator
SPN032672_RS04485	rlmH	842604..843083 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPN032672_RS04495	comC/comC1	843365..843490 (+)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SPN032672_RS04500	comD/comD1	843511..844836 (+)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
SPN032672_RS04505	comE	844833..845585 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPN032672_RS04520	-	845828..846370 (-)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
SPN032672_RS14105	-	846549..848152 (+)	1604	Protein_843	YhgE/Pip family protein	-
SPN032672_RS11845	-	848225..849561 (+)	1337	Protein_844	IS3 family transposase	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=57862 SPN032672_RS04505 WP_000866065.1 844833..845585(+) (comE) [Streptococcus pneumoniae SPN032672]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=57862 SPN032672_RS04505 WP_000866065.1 844833..845585(+) (comE) [Streptococcus pneumoniae SPN032672]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408