Detailed information NTG0548069

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: CSB63_RS07870
• Genome accession: NZ_CP089060
• Coordinates: 1483724..1484509 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain CH8
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1478724..1489509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSB63_RS07835 (CSB63_1644)	gatC	1478785..1479087 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
CSB63_RS07840 (CSB63_1645)	-	1479227..1479481 (-)	255	WP_011226449.1	glycosyl transferase	-
CSB63_RS07845 (CSB63_1646)	-	1479494..1479703 (-)	210	WP_011226450.1	glycosyltransferase	-
CSB63_RS07850	-	1480019..1481465 (-)	1447	Protein_1490	6-phospho-beta-glucosidase	-
CSB63_RS07855 (CSB63_1649)	msrA	1481618..1482127 (-)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
CSB63_RS07860	-	1482139..1482987 (-)	849	Protein_1492	MetQ/NlpA family ABC transporter substrate-binding protein	-
CSB63_RS07865 (CSB63_1652)	-	1483110..1483661 (-)	552	WP_134973449.1	cysteine hydrolase family protein	-
CSB63_RS07870 (CSB63_1653)	codY	1483724..1484509 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
CSB63_RS07875 (CSB63_1654)	-	1484769..1485983 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
CSB63_RS07880 (CSB63_1655)	-	1486338..1486790 (+)	453	WP_002946987.1	universal stress protein	-
CSB63_RS07885	-	1486970..1487541 (+)	572	Protein_1497	IS30 family transposase	-
CSB63_RS07890 (CSB63_1657)	-	1487613..1487786 (-)	174	WP_011681546.1	hypothetical protein	-
CSB63_RS07895 (CSB63_1658)	-	1487847..1488221 (-)	375	WP_041828320.1	membrane protein	-
CSB63_RS07900 (CSB63_1659)	pflA	1488433..1489233 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=548069 CSB63_RS07870 WP_002951720.1 1483724..1484509(-) (codY) [Streptococcus thermophilus strain CH8]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=548069 CSB63_RS07870 WP_002951720.1 1483724..1484509(-) (codY) [Streptococcus thermophilus strain CH8]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502