Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SPYOHK_RS06035 Genome accession   NZ_AFRY01000001
Coordinates   617318..617959 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes HKU QMH11M0907901     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 612318..622959
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYOHK_RS06055 (SPYOHK_03075) - 612874..613614 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  SPYOHK_RS06050 (SPYOHK_03080) pknB 613611..615509 (+) 1899 WP_002988962.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SPYOHK_RS06045 (SPYOHK_03085) liaF 615632..616324 (+) 693 WP_002988964.1 cell wall-active antibiotics response protein LiaF -
  SPYOHK_RS06040 (SPYOHK_03090) - 616321..617325 (+) 1005 WP_002983669.1 sensor histidine kinase -
  SPYOHK_RS06035 (SPYOHK_03095) vraR 617318..617959 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  SPYOHK_RS06030 (SPYOHK_03100) - 617996..619396 (+) 1401 WP_002983672.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  SPYOHK_RS06025 (SPYOHK_03105) - 619396..619773 (+) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  SPYOHK_RS06020 (SPYOHK_03110) cysK 619791..620732 (-) 942 WP_002988967.1 cysteine synthase A -
  SPYOHK_RS06015 (SPYOHK_03115) - 620860..621492 (-) 633 WP_002988970.1 YigZ family protein -
  SPYOHK_RS06010 (SPYOHK_03120) comFA/cflA 621547..622872 (+) 1326 WP_002988971.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=53961 SPYOHK_RS06035 WP_002983671.1 617318..617959(+) (vraR) [Streptococcus pyogenes HKU QMH11M0907901]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=53961 SPYOHK_RS06035 WP_002983671.1 617318..617959(+) (vraR) [Streptococcus pyogenes HKU QMH11M0907901]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCCTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment