NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	I6G42_RS05960	Genome accession	NZ_CP065707
Coordinates	1219318..1219992 (+)	Length	224 a.a.
NCBI ID	WP_000590630.1	Uniprot ID	A0A4V0BT06
Organism	Streptococcus oralis strain FDAARGOS_885
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1214318..1224992

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G42_RS05935 (I6G42_05935)	-	1214607..1215107 (+)	501	WP_000403619.1	NUDIX hydrolase	-
I6G42_RS05940 (I6G42_05940)	-	1215085..1215444 (+)	360	WP_000800853.1	hypothetical protein	-
I6G42_RS05945 (I6G42_05945)	-	1215478..1216074 (+)	597	WP_001101063.1	DUF6707 family protein	-
I6G42_RS05950 (I6G42_05950)	-	1216099..1216539 (+)	441	WP_000188803.1	ASCH domain-containing protein	-
I6G42_RS05955 (I6G42_05955)	-	1216662..1219208 (+)	2547	WP_001149137.1	M1 family metallopeptidase	-
I6G42_RS05960 (I6G42_05960)	ciaR	1219318..1219992 (+)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
I6G42_RS05965 (I6G42_05965)	ciaH	1219982..1221319 (+)	1338	WP_000482352.1	sensor histidine kinase	Regulator
I6G42_RS05970 (I6G42_05970)	-	1221384..1221668 (-)	285	WP_001111509.1	DUF3270 domain-containing protein	-
I6G42_RS05975 (I6G42_05975)	-	1222054..1223109 (+)	1056	WP_000280274.1	ABC transporter permease	-
I6G42_RS05980 (I6G42_05980)	-	1223123..1223803 (+)	681	WP_000125736.1	ABC transporter ATP-binding protein	-
I6G42_RS05985 (I6G42_05985)	-	1223929..1224858 (+)	930	WP_038805085.1	peptidase U32 family protein	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25479.29 Da Isoelectric Point: 4.2660

                                >NTDB_id=513306 I6G42_RS05960 WP_000590630.1 1219318..1219992(+) (ciaR) [Streptococcus oralis strain FDAARGOS_885]

MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

Download Length: 675 bp

                                >NTDB_id=513306 I6G42_RS05960 WP_000590630.1 1219318..1219992(+) (ciaR) [Streptococcus oralis strain FDAARGOS_885]

ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCTGATGT

CATGCAGGTCTTTGATGGTGAAGAAGGACTTTACGAAGCTGAGAGTGGCGTTTATGACTTGATTCTGCTTGACCTCATGT

TGCCTGAAAAAAATGGCTTCCAAGTTTTGAAAGAATTGCGTGAAAAAGGAATTACAACCCCTGTCCTTATCATGACTGCT

AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCAGATGATTATCTGACCAAGCCTTTCTACCTTGAAGA

ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAATACCTTGACCTATGGGGATATTGTCG

TCAACCTTTCAACGAATGAAGTAAAAGTGGAAGATACTCCTGTGGAACTGCTTGGAAAAGAGTTTGAGTTATTGGTTTAC

TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACTAT

TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGGACAGCCTTTGCTGAGAATCTTCAAACCTTGC

GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae TIGR4	97.768	100	0.978
ciaR	Streptococcus pneumoniae D39	97.768	100	0.978
ciaR	Streptococcus pneumoniae R6	97.768	100	0.978
ciaR	Streptococcus pneumoniae Rx1	97.768	100	0.978
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366

Detailed information NTG0513306