Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   KE3_RS04825 Genome accession   NC_021900
Coordinates   952387..954219 (-) Length   610 a.a.
NCBI ID   WP_020916757.1    Uniprot ID   A0AB33ALJ3
Organism   Streptococcus lutetiensis 033     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 947387..959219
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KE3_RS10180 (KE3_0989) - 947653..950088 (-) 2436 WP_020916753.1 putative cross-wall-targeting lipoprotein signal domain-containing proteiin -
  KE3_RS04810 (KE3_0990) - 950116..950847 (-) 732 WP_020916754.1 LPXTG cell wall anchor domain-containing protein -
  KE3_RS04815 (KE3_0991) - 950862..951929 (-) 1068 WP_020916755.1 hypothetical protein -
  KE3_RS04820 (KE3_0992) - 951944..952294 (-) 351 WP_020916756.1 TrbC/VirB2 family protein -
  KE3_RS04825 (KE3_0993) clpE 952387..954219 (-) 1833 WP_020916757.1 AAA family ATPase Regulator
  KE3_RS04830 (KE3_0994) - 954221..955969 (-) 1749 WP_020916758.1 type IA DNA topoisomerase -

Sequence

Protein


Download         Length: 610 a.a.        Molecular weight: 68278.02 Da        Isoelectric Point: 5.1658

>NTDB_id=50046 KE3_RS04825 WP_020916757.1 952387..954219(-) (clpE) [Streptococcus lutetiensis 033]
MTNSSQTPFLEKYTDNLSAKIAQKETDYQVYGRDKEVAAVITSLRRRTKNNPVLVGEAGVGKTAIVEGLTLAILKGGVPE
DLQGLTVRSLELSSLMTGEDGGFIAKFKKIIEEMVATRGKNLLFIDEFHTIVGAGSQEGQALDAGNIIKPVLARGDIQLI
GATTLDEFHDYVETDRALERRMQPIMVDEPSQPQAIRMIDQAKRIYEDYHHIAISHEAVKQAVSLSVRYITDRFLPDKAF
DLIDEAATIASAEKKTVVTEYEIAQVLKNSTGIPITTILKADKDRLEDLTEKLKRRVKGQDEAISAIVDAITIAQVGLQD
ENKPISSFLFLGPTGVGKTELSKAVAEALFDDENAMIRFDMSEYKQKEDVVKFIGDRATRTKGQLTESVKQKPYSVLLLD
EVEKAHSEVMDIFLQVLDDGRLTDSTGRVISFKNTIVIMTTNVGSQKIINKADLKGNFKSLSDRERLQFEKSMDSELQTE
FRPEFLNRIENKLIFNLLERDVIEEIAVKNLEEISERMAKQNLSLTYEPSLITYLSDVGTDVKNGARPLERLIKRKVLAP
IAIKSLELSKTDVTYHIHLWVEGEAPDQNHRQDQRQICLSVKDSLASLFS

Nucleotide


Download         Length: 1833 bp        

>NTDB_id=50046 KE3_RS04825 WP_020916757.1 952387..954219(-) (clpE) [Streptococcus lutetiensis 033]
ATGACCAACAGCTCCCAAACACCATTCTTGGAAAAATACACCGATAACTTATCTGCTAAGATTGCACAAAAAGAGACTGA
TTATCAGGTTTACGGTCGTGACAAAGAGGTGGCGGCAGTTATCACCTCTCTTCGCAGACGCACTAAAAATAATCCTGTTT
TAGTCGGAGAAGCAGGTGTTGGGAAGACAGCTATTGTTGAAGGGTTGACTTTAGCGATTTTAAAAGGAGGAGTTCCAGAA
GACCTGCAAGGCTTAACCGTTCGTTCCTTAGAATTATCCAGTTTAATGACTGGCGAAGACGGTGGCTTTATTGCCAAATT
CAAAAAGATTATTGAAGAGATGGTGGCAACCCGTGGTAAAAATCTTCTCTTTATTGACGAATTTCATACCATTGTTGGAG
CAGGTAGCCAAGAGGGGCAGGCTCTTGATGCAGGAAATATCATTAAACCAGTGCTTGCCCGTGGCGATATTCAACTTATT
GGTGCCACTACCTTAGATGAATTTCATGACTATGTTGAAACCGACCGAGCTTTGGAGCGACGAATGCAGCCCATTATGGT
AGATGAACCCAGTCAGCCACAAGCCATCCGTATGATTGACCAAGCTAAAAGAATTTATGAAGACTATCATCATATTGCGA
TTAGTCACGAAGCGGTCAAGCAAGCGGTTAGTCTATCCGTACGTTATATCACTGATCGCTTTCTTCCTGATAAAGCATTC
GATTTAATTGATGAAGCAGCCACGATTGCGTCAGCTGAGAAAAAGACAGTAGTCACCGAGTATGAGATTGCTCAAGTCCT
TAAGAATAGCACTGGAATTCCTATCACAACGATTTTAAAAGCGGATAAAGACCGCTTAGAAGATTTAACGGAGAAACTTA
AACGGCGGGTAAAAGGACAAGATGAGGCGATTTCAGCCATTGTGGATGCCATTACCATTGCGCAAGTAGGTCTTCAAGAT
GAAAATAAGCCGATTTCATCTTTCCTCTTTTTGGGACCAACAGGTGTCGGGAAAACAGAGTTATCAAAAGCTGTTGCGGA
AGCGCTCTTTGATGATGAAAACGCCATGATTCGTTTTGACATGTCTGAATACAAGCAAAAAGAAGATGTGGTGAAATTTA
TCGGTGACAGGGCTACTCGCACTAAGGGTCAGCTAACAGAAAGTGTGAAACAAAAACCTTACAGTGTCTTATTACTTGAT
GAGGTTGAGAAAGCCCATAGTGAAGTGATGGATATATTTCTTCAGGTGCTTGATGATGGCCGTCTAACCGATAGTACAGG
TCGAGTGATTAGTTTTAAAAACACCATTGTGATCATGACCACCAATGTTGGCTCTCAAAAAATTATCAACAAGGCTGATC
TAAAAGGGAATTTTAAAAGTCTTTCTGACCGTGAACGCCTGCAATTTGAAAAATCGATGGATAGCGAACTACAAACTGAA
TTTCGTCCTGAGTTTCTCAACCGTATTGAAAACAAACTCATTTTTAACCTTTTGGAACGAGATGTCATTGAAGAAATTGC
GGTTAAAAATTTAGAGGAAATTTCAGAGCGGATGGCAAAACAAAATCTGAGTCTTACCTATGAACCAAGTTTAATCACTT
ACCTGTCTGATGTAGGAACTGATGTTAAAAATGGTGCTCGACCTTTGGAACGATTGATTAAGCGAAAAGTCTTAGCTCCT
ATTGCAATAAAGAGCTTAGAACTATCTAAAACCGATGTAACCTATCATATTCATCTCTGGGTTGAAGGGGAAGCACCAGA
CCAAAATCATAGGCAAGATCAACGGCAGATTTGTTTAAGTGTTAAGGACAGTTTAGCAAGTTTGTTTAGTTAA

Domains

Predicted by InterProScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(323-490)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(498-566)

AAA lid domain (AAA_lid_9)

(192-269)

ATPase family associated with various cellular activities (AAA) (AAA)

(53-165)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0AB33ALJ3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

43.415

100

0.438
  clpE Streptococcus pneumoniae TIGR4

42.626

100

0.431
  clpE Streptococcus pneumoniae Rx1

42.626

100

0.431
  clpE Streptococcus pneumoniae D39

42.626

100

0.431
  clpE Streptococcus pneumoniae R6

42.626

100

0.431
  clpC Lactococcus lactis subsp. cremoris KW2

41.599

100

0.418
  clpC Streptococcus thermophilus LMD-9

41.611

97.705

0.407
  clpC Streptococcus mutans UA159

40.894

99.016

0.405
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

39.742

100

0.403
  clpC Streptococcus thermophilus LMG 18311

41.275

97.705

0.403
  clpC Streptococcus pneumoniae Rx1

40.563

99.016

0.402
  clpC Streptococcus pneumoniae D39

40.563

99.016

0.402
  clpC Streptococcus pneumoniae TIGR4

40.397

99.016

0.4