Detailed information NTG0483625

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7U05_RS07480
• Genome accession: NZ_CP072443
• Coordinates: 1444718..1445503 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24724
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1439718..1450503

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7U05_RS07445 (J7U05_07425)	gatC	1439782..1440084 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7U05_RS07450	-	1440224..1440385 (-)	162	WP_232975550.1	hypothetical protein	-
J7U05_RS07455 (J7U05_07435)	-	1440417..1440701 (-)	285	WP_232973492.1	glycosyltransferase	-
J7U05_RS07460 (J7U05_07440)	-	1441017..1442458 (-)	1442	Protein_1415	6-phospho-beta-glucosidase	-
J7U05_RS07465 (J7U05_07445)	msrA	1442611..1443120 (-)	510	WP_041829085.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7U05_RS07470 (J7U05_07450)	-	1443132..1443980 (-)	849	WP_116920342.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7U05_RS07475 (J7U05_07455)	-	1444104..1444655 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
J7U05_RS07480 (J7U05_07460)	codY	1444718..1445503 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7U05_RS07485 (J7U05_07465)	-	1445763..1446977 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
J7U05_RS07490 (J7U05_07470)	-	1447332..1447784 (+)	453	WP_002946987.1	universal stress protein	-
J7U05_RS07495 (J7U05_07475)	-	1447964..1448535 (+)	572	Protein_1422	IS30 family transposase	-
J7U05_RS07500 (J7U05_07480)	-	1448607..1448780 (-)	174	WP_011681546.1	hypothetical protein	-
J7U05_RS07505 (J7U05_07485)	-	1448841..1449215 (-)	375	WP_011681547.1	membrane protein	-
J7U05_RS07510 (J7U05_07490)	pflA	1449427..1450227 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=483625 J7U05_RS07480 WP_002951720.1 1444718..1445503(-) (codY) [Streptococcus thermophilus strain S24724]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=483625 J7U05_RS07480 WP_002951720.1 1444718..1445503(-) (codY) [Streptococcus thermophilus strain S24724]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502