Detailed information NTG0483524

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7T63_RS07935
• Genome accession: NZ_CP072442
• Coordinates: 1512689..1513474 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24726
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1507689..1518474

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7T63_RS07900 (J7T63_07840)	gatC	1507752..1508054 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7T63_RS07905 (J7T63_07845)	-	1508194..1508448 (-)	255	WP_024010053.1	glycosyl transferase	-
J7T63_RS07910 (J7T63_07850)	-	1508461..1508670 (-)	210	WP_080998437.1	glycosyltransferase	-
J7T63_RS07915 (J7T63_07855)	-	1508986..1510429 (-)	1444	Protein_1506	6-phospho-beta-glucosidase	-
J7T63_RS07920 (J7T63_07860)	msrA	1510582..1511091 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7T63_RS07925 (J7T63_07865)	-	1511103..1511951 (-)	849	Protein_1508	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7T63_RS07930 (J7T63_07870)	-	1512075..1512626 (-)	552	WP_084826114.1	cysteine hydrolase family protein	-
J7T63_RS07935 (J7T63_07875)	codY	1512689..1513474 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7T63_RS07940 (J7T63_07880)	-	1513734..1514948 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7T63_RS07945 (J7T63_07885)	-	1515303..1515755 (+)	453	WP_002946987.1	universal stress protein	-
J7T63_RS07950	-	1515935..1516506 (+)	572	Protein_1513	IS30 family transposase	-
J7T63_RS07955	-	1516578..1517174 (-)	597	WP_232086461.1	hypothetical protein	-
J7T63_RS07960 (J7T63_07895)	pflA	1517386..1518186 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=483524 J7T63_RS07935 WP_002951720.1 1512689..1513474(-) (codY) [Streptococcus thermophilus strain S24726]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=483524 J7T63_RS07935 WP_002951720.1 1512689..1513474(-) (codY) [Streptococcus thermophilus strain S24726]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502