Detailed information NTG0483322

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7U24_RS07975
• Genome accession: NZ_CP072440
• Coordinates: 1525356..1526141 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24730
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1520356..1531141

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7U24_RS07940 (J7U24_07915)	gatC	1520419..1520721 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7U24_RS07945 (J7U24_07920)	-	1520861..1521115 (-)	255	WP_024010053.1	glycosyl transferase	-
J7U24_RS07950 (J7U24_07925)	-	1521128..1521337 (-)	210	WP_080998437.1	glycosyltransferase	-
J7U24_RS07955 (J7U24_07930)	-	1521653..1523096 (-)	1444	Protein_1527	6-phospho-beta-glucosidase	-
J7U24_RS07960 (J7U24_07935)	msrA	1523249..1523758 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7U24_RS07965 (J7U24_07940)	-	1523770..1524618 (-)	849	Protein_1529	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7U24_RS07970 (J7U24_07945)	-	1524742..1525293 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
J7U24_RS07975 (J7U24_07950)	codY	1525356..1526141 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7U24_RS07980 (J7U24_07955)	-	1526401..1527615 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7U24_RS07985 (J7U24_07960)	-	1527970..1528422 (+)	453	WP_002946987.1	universal stress protein	-
J7U24_RS07990 (J7U24_07965)	-	1528602..1529173 (+)	572	Protein_1534	IS30 family transposase	-
J7U24_RS07995 (J7U24_07970)	-	1529245..1529418 (-)	174	WP_014621904.1	hypothetical protein	-
J7U24_RS08000 (J7U24_07975)	-	1529479..1529853 (-)	375	WP_232971393.1	hypothetical protein	-
J7U24_RS08005 (J7U24_07980)	pflA	1530065..1530865 (-)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=483322 J7U24_RS07975 WP_002951720.1 1525356..1526141(-) (codY) [Streptococcus thermophilus strain S24730]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=483322 J7U24_RS07975 WP_002951720.1 1525356..1526141(-) (codY) [Streptococcus thermophilus strain S24730]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502