Detailed information NTG0482907

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7T60_RS07570
• Genome accession: NZ_CP072436
• Coordinates: 1442593..1443378 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24735
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1437593..1448378

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7T60_RS07540 (J7T60_07465)	gatC	1437657..1437959 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7T60_RS07545 (J7T60_07470)	-	1438292..1438564 (-)	273	WP_232085675.1	glycosyltransferase	-
J7T60_RS07550 (J7T60_07475)	-	1438892..1440333 (-)	1442	Protein_1433	6-phospho-beta-glucosidase	-
J7T60_RS07555 (J7T60_07480)	msrA	1440486..1440995 (-)	510	WP_002951714.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7T60_RS07560 (J7T60_07485)	-	1441007..1441855 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7T60_RS07565 (J7T60_07490)	-	1441979..1442530 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
J7T60_RS07570 (J7T60_07495)	codY	1442593..1443378 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7T60_RS07575 (J7T60_07500)	-	1443638..1444852 (-)	1215	WP_179971028.1	pyridoxal phosphate-dependent aminotransferase	-
J7T60_RS07580 (J7T60_07505)	-	1445207..1445659 (+)	453	WP_002946987.1	universal stress protein	-
J7T60_RS07585 (J7T60_07510)	-	1445836..1446410 (+)	575	Protein_1440	IS30 family transposase	-
J7T60_RS07590 (J7T60_07515)	-	1446482..1446655 (-)	174	WP_011681546.1	hypothetical protein	-
J7T60_RS07595 (J7T60_07520)	-	1446716..1447090 (-)	375	WP_011681547.1	membrane protein	-
J7T60_RS07600 (J7T60_07525)	pflA	1447302..1448102 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=482907 J7T60_RS07570 WP_002951720.1 1442593..1443378(-) (codY) [Streptococcus thermophilus strain S24735]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=482907 J7T60_RS07570 WP_002951720.1 1442593..1443378(-) (codY) [Streptococcus thermophilus strain S24735]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502