Detailed information NTG0482596

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7U07_RS07735
• Genome accession: NZ_CP072433
• Coordinates: 1487586..1488371 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24743
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1482586..1493371

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7U07_RS07700 (J7U07_07590)	gatC	1482648..1482950 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
J7U07_RS07705 (J7U07_07595)	-	1483125..1483343 (-)	219	WP_242683841.1	glycosyltransferase	-
J7U07_RS07710	-	1483282..1483446 (-)	165	WP_242681665.1	glycosyltransferase	-
J7U07_RS07715 (J7U07_07605)	-	1483883..1485327 (-)	1445	Protein_1466	6-phospho-beta-glucosidase	-
J7U07_RS07720 (J7U07_07610)	msrA	1485480..1485989 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7U07_RS07725 (J7U07_07615)	-	1486001..1486849 (-)	849	WP_372588740.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7U07_RS07730 (J7U07_07620)	-	1486972..1487523 (-)	552	WP_084829819.1	cysteine hydrolase family protein	-
J7U07_RS07735 (J7U07_07625)	codY	1487586..1488371 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7U07_RS07740 (J7U07_07630)	-	1488631..1489845 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7U07_RS07745 (J7U07_07635)	-	1490200..1490652 (+)	453	WP_002946987.1	universal stress protein	-
J7U07_RS07750	-	1490832..1491403 (+)	572	Protein_1473	IS30 family transposase	-
J7U07_RS07755 (J7U07_07640)	-	1491475..1491648 (-)	174	WP_011681546.1	hypothetical protein	-
J7U07_RS07760 (J7U07_07645)	-	1491709..1492083 (-)	375	WP_011681547.1	membrane protein	-
J7U07_RS07765 (J7U07_07650)	pflA	1492295..1493095 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=482596 J7U07_RS07735 WP_002951720.1 1487586..1488371(-) (codY) [Streptococcus thermophilus strain S24743]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=482596 J7U07_RS07735 WP_002951720.1 1487586..1488371(-) (codY) [Streptococcus thermophilus strain S24743]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502