Detailed information NTG0482460

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: J7U00_RS02130
• Genome accession: NZ_CP072431
• Coordinates: 393726..394511 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain S24745
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 388726..399511

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J7U00_RS02100 (J7U00_02115)	pflA	389002..389802 (+)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-
J7U00_RS02105 (J7U00_02120)	-	390014..390388 (+)	375	WP_011681547.1	membrane protein	-
J7U00_RS02110 (J7U00_02125)	-	390449..390622 (+)	174	WP_011681546.1	hypothetical protein	-
J7U00_RS02115 (J7U00_02130)	-	390694..391265 (-)	572	Protein_409	IS30 family transposase	-
J7U00_RS02120 (J7U00_02135)	-	391445..391897 (-)	453	WP_002946987.1	universal stress protein	-
J7U00_RS02125 (J7U00_02140)	-	392252..393466 (+)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
J7U00_RS02130 (J7U00_02145)	codY	393726..394511 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
J7U00_RS02135 (J7U00_02150)	-	394574..395125 (+)	552	WP_002946999.1	cysteine hydrolase family protein	-
J7U00_RS02140 (J7U00_02155)	-	395249..396097 (+)	849	Protein_414	MetQ/NlpA family ABC transporter substrate-binding protein	-
J7U00_RS02145 (J7U00_02160)	msrA	396109..396618 (+)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J7U00_RS02150 (J7U00_02165)	-	396771..398215 (+)	1445	Protein_416	6-phospho-beta-glucosidase	-
J7U00_RS02155	-	398652..398816 (+)	165	WP_242681665.1	glycosyltransferase	-
J7U00_RS02160 (J7U00_02175)	-	398776..398973 (+)	198	WP_242681688.1	glycosyltransferase	-
J7U00_RS02165 (J7U00_02180)	gatC	399148..399450 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=482460 J7U00_RS02130 WP_002951720.1 393726..394511(+) (codY) [Streptococcus thermophilus strain S24745]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=482460 J7U00_RS02130 WP_002951720.1 393726..394511(+) (codY) [Streptococcus thermophilus strain S24745]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502