Detailed information NTG0482049

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IC588_RS09900
• Genome accession: NZ_CP061349
• Coordinates: 2000795..2001838 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MSSA01
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1995795..2006838

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IC588_RS09870 (IC588_09870)	-	1996217..1997473 (-)	1257	WP_072419726.1	aminopeptidase	-
IC588_RS09875 (IC588_09875)	-	1997476..1997676 (-)	201	WP_000180460.1	DUF1128 family protein	-
IC588_RS09880 (IC588_09880)	-	1997823..1998287 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IC588_RS09885 (IC588_09885)	-	1998294..1998569 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
IC588_RS09890 (IC588_09890)	-	1998847..2000064 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IC588_RS09895 (IC588_09895)	vraR	2000176..2000805 (-)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
IC588_RS09900 (IC588_09900)	vraS	2000795..2001838 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IC588_RS09905 (IC588_09905)	liaF	2001835..2002536 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IC588_RS09910 (IC588_09910)	-	2002551..2002937 (-)	387	WP_001110179.1	hypothetical protein	-
IC588_RS09915 (IC588_09915)	map	2003154..2003912 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IC588_RS09920 (IC588_09920)	-	2004443..2005429 (+)	987	WP_000999713.1	FUSC family protein	-
IC588_RS09925 (IC588_09925)	-	2005860..2006273 (-)	414	WP_001566709.1	hypothetical protein	-
IC588_RS09930 (IC588_09930)	-	2006302..2006412 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=482049 IC588_RS09900 WP_001017131.1 2000795..2001838(-) (vraS) [Staphylococcus aureus strain MSSA01]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=482049 IC588_RS09900 WP_001017131.1 2000795..2001838(-) (vraS) [Staphylococcus aureus strain MSSA01]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1