Detailed information NTG0474148

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: H6X75_RS04520
• Genome accession: NZ_CP060156
• Coordinates: 893392..895632 (+)
• Length: 746 a.a.
• NCBI ID: WP_000942387.1
• Uniprot ID: A0AAX3HGB1
• Organism: Streptococcus pneumoniae strain PZ900700608
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 888392..900632

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H6X75_RS04490 (H6X75_04475)	-	888542..889510 (+)	969	WP_000658183.1	PhoH family protein	-
H6X75_RS04495 (H6X75_04485)	-	889703..890203 (+)	501	WP_000566983.1	GNAT family N-acetyltransferase	-
H6X75_RS04500 (H6X75_04490)	-	890206..890532 (+)	327	Protein_897	TfoX/Sxy family protein	-
H6X75_RS04505	ald	890833..891944 (-)	1112	Protein_898	alanine dehydrogenase	-
H6X75_RS04510 (H6X75_04510)	-	892121..892690 (+)	570	WP_000443744.1	GNAT family N-acetyltransferase	-
H6X75_RS04515 (H6X75_04515)	comEA/celA/cilE	892758..893408 (+)	651	WP_000387331.1	ComEA family DNA-binding protein	Machinery gene
H6X75_RS04520 (H6X75_04520)	comEC/celB	893392..895632 (+)	2241	WP_000942387.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
H6X75_RS04525 (H6X75_04525)	-	895774..895998 (+)	225	WP_001813351.1	hypothetical protein	-
H6X75_RS04530 (H6X75_04530)	-	896030..896617 (+)	588	WP_000945253.1	ABC transporter ATP-binding protein	-
H6X75_RS04535 (H6X75_04535)	-	896621..897802 (+)	1182	WP_000655954.1	hypothetical protein	-
H6X75_RS04540 (H6X75_04540)	infC	898109..898639 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
H6X75_RS04545 (H6X75_04545)	rpmI	898672..898872 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
H6X75_RS04550 (H6X75_04550)	rplT	898924..899283 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
H6X75_RS04555 (H6X75_04555)	-	899341..899721 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84545.20 Da
• Isoelectric Point: 9.7371

>NTDB_id=474148 H6X75_RS04520 WP_000942387.1 893392..895632(+) (comEC/celB) [Streptococcus pneumoniae strain PZ900700608]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPLSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWNSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=474148 H6X75_RS04520 WP_000942387.1 893392..895632(+) (comEC/celB) [Streptococcus pneumoniae strain PZ900700608]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTTGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAAATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCCCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGGTTTAAAGGTTGGAATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (30-177)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae Rx1	97.319	100	0.973
comEC/celB	Streptococcus pneumoniae D39	97.319	100	0.973
comEC/celB	Streptococcus pneumoniae R6	97.319	100	0.973
comEC/celB	Streptococcus pneumoniae TIGR4	97.319	100	0.973
comEC/celB	Streptococcus mitis NCTC 12261	92.483	99.866	0.924
comEC/celB	Streptococcus mitis SK321	92.225	100	0.922
comEC	Lactococcus lactis subsp. cremoris KW2	44.804	99.33	0.445