Detailed information NTG0451196

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STMM8_RS07430
• Genome accession: NZ_CP065787
• Coordinates: 1427750..1428535 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain MM8
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1422750..1433535

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STMM8_RS07395 (STMM8_07385)	gatC	1422816..1423118 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STMM8_RS07400 (STMM8_07390)	-	1423258..1423512 (-)	255	WP_011226449.1	glycosyl transferase	-
STMM8_RS07405 (STMM8_07395)	-	1423525..1423734 (-)	210	WP_011226450.1	glycosyltransferase	-
STMM8_RS07410 (STMM8_07400)	-	1424050..1425491 (-)	1442	Protein_1405	6-phospho-beta-glucosidase	-
STMM8_RS07415 (STMM8_07405)	msrA	1425644..1426153 (-)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STMM8_RS07420 (STMM8_07410)	-	1426165..1427013 (-)	849	WP_022096458.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STMM8_RS07425 (STMM8_07415)	-	1427136..1427687 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
STMM8_RS07430 (STMM8_07420)	codY	1427750..1428535 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STMM8_RS07435 (STMM8_07425)	-	1428795..1430009 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
STMM8_RS07440 (STMM8_07430)	-	1430364..1430816 (+)	453	WP_002946987.1	universal stress protein	-
STMM8_RS07445	-	1430993..1431567 (+)	575	Protein_1412	IS30 family transposase	-
STMM8_RS07450	-	1431639..1432247 (-)	609	WP_002946982.1	hypothetical protein	-
STMM8_RS07455 (STMM8_07440)	pflA	1432459..1433259 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=451196 STMM8_RS07430 WP_002951720.1 1427750..1428535(-) (codY) [Streptococcus thermophilus strain MM8]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=451196 STMM8_RS07430 WP_002951720.1 1427750..1428535(-) (codY) [Streptococcus thermophilus strain MM8]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502