Detailed information NTG0449695

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST4147_RS07605
• Genome accession: NZ_CP065504
• Coordinates: 1455247..1456032 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 4147
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1450247..1461032

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4147_RS07570 (ST4147_07575)	gatC	1450313..1450615 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST4147_RS07575 (ST4147_07580)	-	1450755..1451009 (-)	255	WP_011226449.1	glycosyl transferase	-
ST4147_RS07580 (ST4147_07585)	-	1451022..1451231 (-)	210	WP_011226450.1	glycosyltransferase	-
ST4147_RS07585 (ST4147_07590)	-	1451547..1452988 (-)	1442	Protein_1440	6-phospho-beta-glucosidase	-
ST4147_RS07590 (ST4147_07595)	msrA	1453141..1453650 (-)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST4147_RS07595 (ST4147_07600)	-	1453662..1454510 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST4147_RS07600 (ST4147_07605)	-	1454633..1455184 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
ST4147_RS07605 (ST4147_07610)	codY	1455247..1456032 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST4147_RS07610 (ST4147_07615)	-	1456292..1457506 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
ST4147_RS07615 (ST4147_07620)	-	1457861..1458313 (+)	453	WP_002946987.1	universal stress protein	-
ST4147_RS07620	-	1458493..1459064 (+)	572	Protein_1447	IS30 family transposase	-
ST4147_RS07625 (ST4147_07625)	-	1459280..1459750 (-)	471	WP_011227497.1	membrane protein	-
ST4147_RS07630 (ST4147_07630)	pflA	1459956..1460756 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=449695 ST4147_RS07605 WP_002951720.1 1455247..1456032(-) (codY) [Streptococcus thermophilus strain 4147]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=449695 ST4147_RS07605 WP_002951720.1 1455247..1456032(-) (codY) [Streptococcus thermophilus strain 4147]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502