Detailed information NTG0449380

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STAVA116_RS07205
• Genome accession: NZ_CP065498
• Coordinates: 1393450..1394235 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain AVA116
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1388450..1399235

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAVA116_RS07170 (STAVA116_07130)	gatC	1388515..1388817 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STAVA116_RS07175 (STAVA116_07135)	-	1388957..1389211 (-)	255	WP_041827766.1	glycosyl transferase	-
STAVA116_RS07180 (STAVA116_07140)	-	1389224..1389433 (-)	210	WP_002951711.1	glycosyltransferase	-
STAVA116_RS07185 (STAVA116_07145)	-	1389749..1391190 (-)	1442	Protein_1373	6-phospho-beta-glucosidase	-
STAVA116_RS07190 (STAVA116_07150)	msrA	1391343..1391852 (-)	510	WP_084829818.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STAVA116_RS07195 (STAVA116_07155)	-	1391864..1392712 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STAVA116_RS07200 (STAVA116_07160)	-	1392836..1393387 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
STAVA116_RS07205 (STAVA116_07165)	codY	1393450..1394235 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STAVA116_RS07210 (STAVA116_07170)	-	1394495..1395709 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STAVA116_RS07215 (STAVA116_07175)	-	1396064..1396516 (+)	453	WP_002946987.1	universal stress protein	-
STAVA116_RS07220 (STAVA116_07180)	-	1396695..1397266 (+)	572	Protein_1380	IS30 family transposase	-
STAVA116_RS07225 (STAVA116_07185)	-	1397338..1397511 (-)	174	WP_172838681.1	hypothetical protein	-
STAVA116_RS07230 (STAVA116_07190)	-	1397572..1397946 (-)	375	WP_041828320.1	membrane protein	-
STAVA116_RS07235 (STAVA116_07195)	pflA	1398158..1398958 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=449380 STAVA116_RS07205 WP_002951720.1 1393450..1394235(-) (codY) [Streptococcus thermophilus strain AVA116]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=449380 STAVA116_RS07205 WP_002951720.1 1393450..1394235(-) (codY) [Streptococcus thermophilus strain AVA116]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACGGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502