Detailed information NTG0449278

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST4067_RS07590
• Genome accession: NZ_CP065496
• Coordinates: 1456611..1457396 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 4067
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1451611..1462396

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4067_RS07560 (ST4067_07575)	gatC	1451676..1451978 (-)	303	WP_096832626.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST4067_RS07565 (ST4067_07585)	-	1452311..1452583 (-)	273	WP_232510048.1	glycosyltransferase	-
ST4067_RS07570 (ST4067_07590)	-	1452911..1454352 (-)	1442	Protein_1437	6-phospho-beta-glucosidase	-
ST4067_RS07575 (ST4067_07595)	msrA	1454505..1455014 (-)	510	WP_180473319.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST4067_RS07580 (ST4067_07600)	-	1455026..1455874 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST4067_RS07585 (ST4067_07605)	-	1455997..1456548 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
ST4067_RS07590 (ST4067_07610)	codY	1456611..1457396 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST4067_RS07595 (ST4067_07615)	-	1457656..1458870 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
ST4067_RS07600 (ST4067_07620)	-	1459225..1459677 (+)	453	WP_002946987.1	universal stress protein	-
ST4067_RS07605	-	1459857..1460428 (+)	572	Protein_1444	IS30 family transposase	-
ST4067_RS07610 (ST4067_07625)	-	1460500..1460673 (-)	174	WP_232972411.1	hypothetical protein	-
ST4067_RS07615 (ST4067_07630)	-	1460734..1461108 (-)	375	WP_041828320.1	membrane protein	-
ST4067_RS07620 (ST4067_07635)	pflA	1461320..1462120 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=449278 ST4067_RS07590 WP_002951720.1 1456611..1457396(-) (codY) [Streptococcus thermophilus strain 4067]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=449278 ST4067_RS07590 WP_002951720.1 1456611..1457396(-) (codY) [Streptococcus thermophilus strain 4067]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACGGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502