Detailed information NTG0449174

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STCNRZ385_RS07895
• Genome accession: NZ_CP065495
• Coordinates: 1520766..1521551 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain CNRZ385
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1515766..1526551

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STCNRZ385_RS07860 (STCNRZ385_07845)	gatC	1515830..1516132 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STCNRZ385_RS07865 (STCNRZ385_07850)	-	1516307..1516525 (-)	219	WP_014621899.1	glycosyl transferase	-
STCNRZ385_RS07870	-	1516464..1516628 (-)	165	WP_231838381.1	glycosyltransferase	-
STCNRZ385_RS07875 (STCNRZ385_07860)	-	1517065..1518506 (-)	1442	Protein_1496	6-phospho-beta-glucosidase	-
STCNRZ385_RS07880 (STCNRZ385_07865)	msrA	1518659..1519168 (-)	510	WP_041829085.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STCNRZ385_RS07885 (STCNRZ385_07870)	-	1519180..1520028 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STCNRZ385_RS07890 (STCNRZ385_07875)	-	1520152..1520703 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
STCNRZ385_RS07895 (STCNRZ385_07880)	codY	1520766..1521551 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STCNRZ385_RS07900 (STCNRZ385_07885)	-	1521811..1523025 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
STCNRZ385_RS07905 (STCNRZ385_07890)	-	1523380..1523832 (+)	453	WP_002946987.1	universal stress protein	-
STCNRZ385_RS07910 (STCNRZ385_07895)	-	1524012..1524583 (+)	572	Protein_1503	IS30 family transposase	-
STCNRZ385_RS07915 (STCNRZ385_07900)	-	1524655..1524828 (-)	174	WP_014621904.1	hypothetical protein	-
STCNRZ385_RS07920 (STCNRZ385_07905)	-	1524895..1525263 (-)	369	WP_014621905.1	membrane protein	-
STCNRZ385_RS07925 (STCNRZ385_07910)	pflA	1525475..1526275 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=449174 STCNRZ385_RS07895 WP_002951720.1 1520766..1521551(-) (codY) [Streptococcus thermophilus strain CNRZ385]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=449174 STCNRZ385_RS07895 WP_002951720.1 1520766..1521551(-) (codY) [Streptococcus thermophilus strain CNRZ385]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502