Detailed information NTG0449069

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST4021_RS07735
• Genome accession: NZ_CP065493
• Coordinates: 1502622..1503407 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 4021
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1497622..1508407

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4021_RS07700 (ST4021_07735)	gatC	1497687..1497989 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST4021_RS07705	-	1498129..1498290 (-)	162	WP_224103235.1	hypothetical protein	-
ST4021_RS07710	-	1498322..1498594 (-)	273	WP_224103183.1	glycosyltransferase	-
ST4021_RS07715 (ST4021_07750)	-	1498921..1500362 (-)	1442	Protein_1466	6-phospho-beta-glucosidase	-
ST4021_RS07720 (ST4021_07755)	msrA	1500515..1501024 (-)	510	WP_041827768.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST4021_RS07725 (ST4021_07760)	-	1501036..1501884 (-)	849	WP_011681545.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST4021_RS07730 (ST4021_07765)	-	1502008..1502559 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
ST4021_RS07735 (ST4021_07770)	codY	1502622..1503407 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST4021_RS07740 (ST4021_07775)	-	1503667..1504881 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
ST4021_RS07745 (ST4021_07780)	-	1505236..1505688 (+)	453	WP_002946987.1	universal stress protein	-
ST4021_RS07750 (ST4021_07785)	-	1505865..1506439 (+)	575	Protein_1473	IS30 family transposase	-
ST4021_RS07755 (ST4021_07790)	-	1506511..1506684 (-)	174	WP_011681546.1	hypothetical protein	-
ST4021_RS07760 (ST4021_07795)	-	1506745..1507119 (-)	375	WP_011681547.1	membrane protein	-
ST4021_RS07765 (ST4021_07800)	pflA	1507331..1508131 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=449069 ST4021_RS07735 WP_002951720.1 1502622..1503407(-) (codY) [Streptococcus thermophilus strain 4021]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=449069 ST4021_RS07735 WP_002951720.1 1502622..1503407(-) (codY) [Streptococcus thermophilus strain 4021]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502