Detailed information NTG0448762

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STCNRZ1575_RS07855
• Genome accession: NZ_CP065490
• Coordinates: 1508814..1509599 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain CNRZ1575
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1503814..1514599

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STCNRZ1575_RS07825 (STCNRZ1575_07800)	gatC	1503880..1504182 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STCNRZ1575_RS07830	-	1504515..1504787 (-)	273	WP_224103183.1	glycosyltransferase	-
STCNRZ1575_RS07835 (STCNRZ1575_07810)	-	1505114..1506555 (-)	1442	Protein_1476	6-phospho-beta-glucosidase	-
STCNRZ1575_RS07840 (STCNRZ1575_07815)	msrA	1506708..1507217 (-)	510	WP_260214192.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STCNRZ1575_RS07845 (STCNRZ1575_07820)	-	1507229..1508080 (-)	852	WP_260214193.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STCNRZ1575_RS07850 (STCNRZ1575_07825)	-	1508200..1508751 (-)	552	WP_084829819.1	isochorismatase family cysteine hydrolase	-
STCNRZ1575_RS07855 (STCNRZ1575_07830)	codY	1508814..1509599 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STCNRZ1575_RS07860 (STCNRZ1575_07835)	-	1509859..1511073 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STCNRZ1575_RS07865 (STCNRZ1575_07840)	-	1511428..1511880 (+)	453	WP_002946987.1	universal stress protein	-
STCNRZ1575_RS07870	-	1512060..1512631 (+)	572	Protein_1483	IS30 family transposase	-
STCNRZ1575_RS07875	-	1512703..1513299 (-)	597	WP_232086461.1	hypothetical protein	-
STCNRZ1575_RS07880 (STCNRZ1575_07850)	pflA	1513511..1514311 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448762 STCNRZ1575_RS07855 WP_002951720.1 1508814..1509599(-) (codY) [Streptococcus thermophilus strain CNRZ1575]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448762 STCNRZ1575_RS07855 WP_002951720.1 1508814..1509599(-) (codY) [Streptococcus thermophilus strain CNRZ1575]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
CTACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502