Detailed information NTG0448658

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STCNRZ302_RS07800
• Genome accession: NZ_CP065489
• Coordinates: 1508988..1509773 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain CNRZ302
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1503988..1514773

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STCNRZ302_RS07770 (STCNRZ302_07690)	gatC	1504055..1504357 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STCNRZ302_RS07775	-	1504689..1504961 (-)	273	WP_232085675.1	glycosyltransferase	-
STCNRZ302_RS07780 (STCNRZ302_07700)	-	1505288..1506729 (-)	1442	Protein_1479	6-phospho-beta-glucosidase	-
STCNRZ302_RS07785 (STCNRZ302_07705)	msrA	1506882..1507391 (-)	510	WP_041827768.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STCNRZ302_RS07790 (STCNRZ302_07710)	-	1507403..1508251 (-)	849	WP_011681545.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STCNRZ302_RS07795 (STCNRZ302_07715)	-	1508374..1508925 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
STCNRZ302_RS07800 (STCNRZ302_07720)	codY	1508988..1509773 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STCNRZ302_RS07805 (STCNRZ302_07725)	-	1510033..1511247 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
STCNRZ302_RS07810 (STCNRZ302_07730)	-	1511602..1512054 (+)	453	WP_179970584.1	universal stress protein	-
STCNRZ302_RS07815	-	1512236..1512807 (+)	572	Protein_1486	IS30 family transposase	-
STCNRZ302_RS07820	-	1512879..1513475 (-)	597	WP_232086461.1	hypothetical protein	-
STCNRZ302_RS07825 (STCNRZ302_07740)	pflA	1513687..1514487 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448658 STCNRZ302_RS07800 WP_002951720.1 1508988..1509773(-) (codY) [Streptococcus thermophilus strain CNRZ302]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448658 STCNRZ302_RS07800 WP_002951720.1 1508988..1509773(-) (codY) [Streptococcus thermophilus strain CNRZ302]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502