Detailed information NTG0448556

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STAVA1121_RS07825
• Genome accession: NZ_CP065488
• Coordinates: 1479466..1480251 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain AVA1121
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1474466..1485251

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAVA1121_RS07790 (STAVA1121_07680)	gatC	1474532..1474834 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STAVA1121_RS07795	-	1474974..1475135 (-)	162	WP_224103235.1	hypothetical protein	-
STAVA1121_RS07800	-	1475167..1475439 (-)	273	WP_224103183.1	glycosyltransferase	-
STAVA1121_RS07805 (STAVA1121_07695)	-	1475766..1477207 (-)	1442	Protein_1483	6-phospho-beta-glucosidase	-
STAVA1121_RS07810 (STAVA1121_07700)	msrA	1477360..1477869 (-)	510	WP_041829085.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STAVA1121_RS07815 (STAVA1121_07705)	-	1477881..1478729 (-)	849	WP_179967094.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STAVA1121_RS07820 (STAVA1121_07710)	-	1478853..1479404 (-)	552	WP_173940634.1	isochorismatase family cysteine hydrolase	-
STAVA1121_RS07825 (STAVA1121_07715)	codY	1479466..1480251 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STAVA1121_RS07830 (STAVA1121_07720)	-	1480511..1481725 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
STAVA1121_RS07835 (STAVA1121_07725)	-	1482080..1482532 (+)	453	WP_180477136.1	universal stress protein	-
STAVA1121_RS07840	-	1482745..1482894 (+)	150	WP_232557033.1	hypothetical protein	-
STAVA1121_RS07845	-	1483101..1483283 (+)	183	Protein_1491	IS30 family transposase	-
STAVA1121_RS07850 (STAVA1121_07735)	-	1483355..1483528 (-)	174	WP_011681546.1	hypothetical protein	-
STAVA1121_RS07855 (STAVA1121_07740)	-	1483589..1483963 (-)	375	WP_141326717.1	hypothetical protein	-
STAVA1121_RS07860 (STAVA1121_07745)	pflA	1484173..1484973 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448556 STAVA1121_RS07825 WP_002951720.1 1479466..1480251(-) (codY) [Streptococcus thermophilus strain AVA1121]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448556 STAVA1121_RS07825 WP_002951720.1 1479466..1480251(-) (codY) [Streptococcus thermophilus strain AVA1121]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATCACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502