NTDB

Overview

Name	vicR	Type	Regulator
Locus tag	HQ611_RS04085	Genome accession	NZ_CP053887
Coordinates	754937..755647 (+)	Length	236 a.a.
NCBI ID	WP_000722052.1	Uniprot ID	X5K3L1
Organism	Streptococcus agalactiae strain SS102
Function	repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 749937..760647

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HQ611_RS04060 (HQ611_04025)	-	751045..751611 (+)	567	WP_000592389.1	PepSY domain-containing protein	-
HQ611_RS04065 (HQ611_04030)	-	751660..752310 (-)	651	WP_000100034.1	amino acid ABC transporter permease	-
HQ611_RS04070 (HQ611_04035)	-	752322..753017 (-)	696	WP_000173640.1	amino acid ABC transporter permease	-
HQ611_RS04075 (HQ611_04040)	-	753030..753830 (-)	801	WP_000946171.1	transporter substrate-binding domain-containing protein	-
HQ611_RS04080 (HQ611_04045)	-	753842..754597 (-)	756	WP_000053154.1	amino acid ABC transporter ATP-binding protein	-
HQ611_RS04085 (HQ611_04050)	vicR	754937..755647 (+)	711	WP_000722052.1	response regulator YycF	Regulator
HQ611_RS04090 (HQ611_04055)	vicK	755640..756989 (+)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
HQ611_RS04095 (HQ611_04060)	vicX	756993..757802 (+)	810	WP_001289499.1	MBL fold metallo-hydrolase	Regulator
HQ611_RS04100 (HQ611_04065)	-	757805..758173 (+)	369	WP_000719384.1	YbaN family protein	-
HQ611_RS04105 (HQ611_04070)	rnc	758349..759035 (+)	687	WP_000661526.1	ribonuclease III	-

Sequence

Protein

Download Length: 236 a.a. Molecular weight: 27063.90 Da Isoelectric Point: 4.8246

                                >NTDB_id=448533 HQ611_RS04085 WP_000722052.1 754937..755647(+) (vicR) [Streptococcus agalactiae strain SS102]

MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE

LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide

Download Length: 711 bp

                                >NTDB_id=448533 HQ611_RS04085 WP_000722052.1 754937..755647(+) (vicR) [Streptococcus agalactiae strain SS102]

ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA

GACGGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA

TGCTCCCTGAACTAGATGGTTTAGAAGTGGCTAAAGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCTGCA

AAAGATAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA

ACTTTTGGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGTGCTCAAAATG

CTTCTTCGGATATTACTATTGGTGAGTTGCAAATTTTACCAGACGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA

TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATCGGACAAGTCATGACACGCGAACATTTATTGGA

AACAGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG

ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	X5K3L1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
vicR	Streptococcus mutans UA159	88.983	100	0.89
micA	Streptococcus pneumoniae Cp1015	77.778	99.153	0.771
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.983	98.305	0.462
covR	Streptococcus salivarius strain HSISS4	44.635	98.729	0.441
scnR	Streptococcus mutans UA159	38.559	100	0.386

Detailed information NTG0448533