Detailed information NTG0448451

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STT19_RS07750
• Genome accession: NZ_CP065487
• Coordinates: 1501987..1502772 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain ST19
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1496987..1507772

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STT19_RS07715 (STT19_07740)	gatC	1497051..1497353 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STT19_RS07720 (STT19_07745)	-	1497528..1497746 (-)	219	WP_014621899.1	glycosyl transferase	-
STT19_RS07725	-	1497685..1497849 (-)	165	WP_231838381.1	glycosyltransferase	-
STT19_RS07730 (STT19_07755)	-	1498286..1499727 (-)	1442	Protein_1469	6-phospho-beta-glucosidase	-
STT19_RS07735 (STT19_07760)	msrA	1499880..1500389 (-)	510	WP_024703984.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STT19_RS07740 (STT19_07765)	-	1500401..1501249 (-)	849	WP_024703985.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STT19_RS07745 (STT19_07770)	-	1501373..1501924 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
STT19_RS07750 (STT19_07775)	codY	1501987..1502772 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STT19_RS07755 (STT19_07780)	-	1503032..1504246 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STT19_RS07760 (STT19_07785)	-	1504601..1505053 (+)	453	WP_002946987.1	universal stress protein	-
STT19_RS07765 (STT19_07790)	-	1505233..1505804 (+)	572	Protein_1476	IS30 family transposase	-
STT19_RS07770 (STT19_07795)	-	1505876..1506049 (-)	174	WP_011681546.1	hypothetical protein	-
STT19_RS07775 (STT19_07800)	-	1506110..1506484 (-)	375	WP_084825650.1	hypothetical protein	-
STT19_RS07780 (STT19_07805)	pflA	1506696..1507496 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448451 STT19_RS07750 WP_002951720.1 1501987..1502772(-) (codY) [Streptococcus thermophilus strain ST19]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448451 STT19_RS07750 WP_002951720.1 1501987..1502772(-) (codY) [Streptococcus thermophilus strain ST19]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502