Detailed information NTG0448347

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STR1_RS07755
• Genome accession: NZ_CP065486
• Coordinates: 1512079..1512864 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain R1
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1507079..1517864

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STR1_RS07720 (STR1_07770)	gatC	1507144..1507446 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STR1_RS07725 (STR1_07775)	-	1507586..1507840 (-)	255	WP_095559434.1	glycosyltransferase	-
STR1_RS07730 (STR1_07780)	-	1507853..1508050 (-)	198	WP_231108739.1	glycosyltransferase	-
STR1_RS07735 (STR1_07785)	-	1508378..1509819 (-)	1442	Protein_1482	6-phospho-beta-glucosidase	-
STR1_RS07740 (STR1_07790)	msrA	1509972..1510481 (-)	510	WP_041827768.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STR1_RS07745 (STR1_07795)	-	1510493..1511341 (-)	849	WP_011681545.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STR1_RS07750 (STR1_07800)	-	1511465..1512016 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
STR1_RS07755 (STR1_07805)	codY	1512079..1512864 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STR1_RS07760 (STR1_07810)	-	1513124..1514338 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STR1_RS07765 (STR1_07815)	-	1514693..1515145 (+)	453	WP_002946987.1	universal stress protein	-
STR1_RS07770 (STR1_07820)	-	1515325..1515896 (+)	572	Protein_1489	IS30 family transposase	-
STR1_RS07775	-	1515968..1516576 (-)	609	WP_232505748.1	hypothetical protein	-
STR1_RS07780 (STR1_07830)	pflA	1516788..1517588 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448347 STR1_RS07755 WP_002951720.1 1512079..1512864(-) (codY) [Streptococcus thermophilus strain R1]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448347 STR1_RS07755 WP_002951720.1 1512079..1512864(-) (codY) [Streptococcus thermophilus strain R1]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502