Detailed information NTG0448200

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STMM20_RS02180
• Genome accession: NZ_CP065485
• Coordinates: 418592..419377 (+)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain MM20
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 413592..424377

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STMM20_RS02150 (STMM20_02165)	pflA	413868..414668 (+)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-
STMM20_RS02155 (STMM20_02170)	-	414880..415254 (+)	375	WP_011681547.1	membrane protein	-
STMM20_RS02160 (STMM20_02175)	-	415315..415488 (+)	174	WP_011681546.1	hypothetical protein	-
STMM20_RS02165	-	415560..416134 (-)	575	Protein_387	IS30 family transposase	-
STMM20_RS02170 (STMM20_02180)	-	416311..416763 (-)	453	WP_002946987.1	universal stress protein	-
STMM20_RS02175 (STMM20_02185)	-	417118..418332 (+)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STMM20_RS02180 (STMM20_02190)	codY	418592..419377 (+)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STMM20_RS02185 (STMM20_02195)	-	419440..419991 (+)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
STMM20_RS02190 (STMM20_02200)	-	420115..420963 (+)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STMM20_RS02195 (STMM20_02205)	msrA	420975..421484 (+)	510	WP_347103601.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STMM20_RS02200 (STMM20_02210)	-	421637..423081 (+)	1445	Protein_394	6-phospho-beta-glucosidase	-
STMM20_RS02205 (STMM20_02215)	-	423445..423606 (+)	162	WP_224102937.1	glycosyltransferase	-
STMM20_RS02210 (STMM20_02220)	-	423619..423837 (+)	219	WP_014621899.1	glycosyl transferase	-
STMM20_RS02215 (STMM20_02225)	gatC	424012..424314 (+)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448200 STMM20_RS02180 WP_002951720.1 418592..419377(+) (codY) [Streptococcus thermophilus strain MM20]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448200 STMM20_RS02180 WP_002951720.1 418592..419377(+) (codY) [Streptococcus thermophilus strain MM20]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502