Detailed information NTG0448137

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STMM1_RS07730
• Genome accession: NZ_CP065484
• Coordinates: 1485104..1485889 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain MM1
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1480104..1490889

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STMM1_RS07695 (STMM1_07645)	gatC	1480166..1480468 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STMM1_RS07700 (STMM1_07650)	-	1480608..1480862 (-)	255	WP_024010053.1	glycosyl transferase	-
STMM1_RS07705 (STMM1_07655)	-	1480875..1481084 (-)	210	WP_080998437.1	glycosyltransferase	-
STMM1_RS07710 (STMM1_07660)	-	1481400..1482844 (-)	1445	Protein_1465	6-phospho-beta-glucosidase	-
STMM1_RS07715 (STMM1_07665)	msrA	1482997..1483506 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STMM1_RS07720 (STMM1_07670)	-	1483518..1484366 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STMM1_RS07725 (STMM1_07675)	-	1484490..1485041 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
STMM1_RS07730 (STMM1_07680)	codY	1485104..1485889 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STMM1_RS07735 (STMM1_07685)	-	1486149..1487363 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STMM1_RS07740 (STMM1_07690)	-	1487718..1488170 (+)	453	WP_002946987.1	universal stress protein	-
STMM1_RS07745 (STMM1_07695)	-	1488350..1488921 (+)	572	Protein_1472	IS30 family transposase	-
STMM1_RS07750 (STMM1_07700)	-	1488993..1489166 (-)	174	WP_011681546.1	hypothetical protein	-
STMM1_RS07755 (STMM1_07705)	-	1489227..1489601 (-)	375	WP_011681547.1	membrane protein	-
STMM1_RS07760 (STMM1_07710)	pflA	1489813..1490613 (-)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=448137 STMM1_RS07730 WP_002951720.1 1485104..1485889(-) (codY) [Streptococcus thermophilus strain MM1]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=448137 STMM1_RS07730 WP_002951720.1 1485104..1485889(-) (codY) [Streptococcus thermophilus strain MM1]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502