Detailed information NTG0447825

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST90730_RS07580
• Genome accession: NZ_CP065481
• Coordinates: 1453821..1454606 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 90730
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1448821..1459606

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST90730_RS07545 (ST90730_07560)	gatC	1448887..1449189 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST90730_RS07550 (ST90730_07565)	-	1449329..1449583 (-)	255	WP_011226449.1	glycosyl transferase	-
ST90730_RS07555 (ST90730_07570)	-	1449596..1449805 (-)	210	WP_011226450.1	glycosyltransferase	-
ST90730_RS07560 (ST90730_07575)	-	1450121..1451562 (-)	1442	Protein_1435	6-phospho-beta-glucosidase	-
ST90730_RS07565 (ST90730_07580)	msrA	1451715..1452224 (-)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST90730_RS07570 (ST90730_07585)	-	1452236..1453084 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST90730_RS07575 (ST90730_07590)	-	1453207..1453758 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
ST90730_RS07580 (ST90730_07595)	codY	1453821..1454606 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST90730_RS07585 (ST90730_07600)	-	1454866..1456080 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
ST90730_RS07590 (ST90730_07605)	-	1456435..1456887 (+)	453	WP_002946987.1	universal stress protein	-
ST90730_RS07595	-	1457067..1457638 (+)	572	Protein_1442	IS30 family transposase	-
ST90730_RS07600 (ST90730_07610)	-	1457854..1458324 (-)	471	WP_011227497.1	membrane protein	-
ST90730_RS07605 (ST90730_07615)	pflA	1458530..1459330 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=447825 ST90730_RS07580 WP_002951720.1 1453821..1454606(-) (codY) [Streptococcus thermophilus strain 90730]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=447825 ST90730_RS07580 WP_002951720.1 1453821..1454606(-) (codY) [Streptococcus thermophilus strain 90730]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502