Detailed information NTG0447613

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST90728_RS07875
• Genome accession: NZ_CP065479
• Coordinates: 1523991..1524776 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 90728
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1518991..1529776

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST90728_RS07840 (ST90728_07835)	gatC	1519055..1519357 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST90728_RS07845 (ST90728_07840)	-	1519497..1519751 (-)	255	WP_206285306.1	glycosyltransferase	-
ST90728_RS07850 (ST90728_07845)	-	1519764..1519973 (-)	210	WP_002951711.1	glycosyltransferase	-
ST90728_RS07855 (ST90728_07850)	-	1520290..1521731 (-)	1442	Protein_1494	6-phospho-beta-glucosidase	-
ST90728_RS07860 (ST90728_07855)	msrA	1521884..1522393 (-)	510	WP_180473319.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST90728_RS07865 (ST90728_07860)	-	1522405..1523253 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST90728_RS07870 (ST90728_07865)	-	1523377..1523928 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
ST90728_RS07875 (ST90728_07870)	codY	1523991..1524776 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST90728_RS07880 (ST90728_07875)	-	1525036..1526250 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
ST90728_RS07885 (ST90728_07880)	-	1526605..1527057 (+)	453	WP_002946987.1	universal stress protein	-
ST90728_RS07890 (ST90728_07885)	-	1527237..1527808 (+)	572	Protein_1501	IS30 family transposase	-
ST90728_RS07895 (ST90728_07890)	-	1527880..1528053 (-)	174	WP_347113961.1	hypothetical protein	-
ST90728_RS07900 (ST90728_07895)	-	1528114..1528488 (-)	375	WP_011681547.1	membrane protein	-
ST90728_RS07905 (ST90728_07900)	pflA	1528700..1529500 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=447613 ST90728_RS07875 WP_002951720.1 1523991..1524776(-) (codY) [Streptococcus thermophilus strain 90728]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=447613 ST90728_RS07875 WP_002951720.1 1523991..1524776(-) (codY) [Streptococcus thermophilus strain 90728]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502