Detailed information NTG0446668

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST1A_RS07770
• Genome accession: NZ_CP065384
• Coordinates: 1509955..1510740 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 1A
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1504955..1515740

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST1A_RS07740 (ST1A_07690)	gatC	1505020..1505322 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST1A_RS07745	-	1505655..1505927 (-)	273	WP_224103183.1	glycosyltransferase	-
ST1A_RS07750 (ST1A_07700)	-	1506254..1507695 (-)	1442	Protein_1473	6-phospho-beta-glucosidase	-
ST1A_RS07755 (ST1A_07705)	msrA	1507848..1508357 (-)	510	WP_041827768.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST1A_RS07760 (ST1A_07710)	-	1508369..1509217 (-)	849	WP_011681545.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST1A_RS07765 (ST1A_07715)	-	1509341..1509892 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
ST1A_RS07770 (ST1A_07720)	codY	1509955..1510740 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST1A_RS07775 (ST1A_07725)	-	1511000..1512214 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
ST1A_RS07780 (ST1A_07730)	-	1512569..1513021 (+)	453	WP_002946987.1	universal stress protein	-
ST1A_RS07785 (ST1A_07735)	-	1513201..1513772 (+)	572	Protein_1480	IS30 family transposase	-
ST1A_RS07790 (ST1A_07740)	-	1513844..1514017 (-)	174	WP_011681546.1	hypothetical protein	-
ST1A_RS07795 (ST1A_07745)	-	1514078..1514452 (-)	375	WP_011681547.1	membrane protein	-
ST1A_RS07800 (ST1A_07750)	pflA	1514664..1515464 (-)	801	WP_101415688.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=446668 ST1A_RS07770 WP_002951720.1 1509955..1510740(-) (codY) [Streptococcus thermophilus strain 1A]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=446668 ST1A_RS07770 WP_002951720.1 1509955..1510740(-) (codY) [Streptococcus thermophilus strain 1A]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502