NTDB

Overview

Name	codY	Type	Regulator
Locus tag	IM723_RS07915	Genome accession	NZ_CP063275
Coordinates	1532746..1533531 (-)	Length	261 a.a.
NCBI ID	WP_002951720.1	Uniprot ID	Q5M305
Organism	Streptococcus thermophilus strain DMST-H2
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1527746..1538531

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IM723_RS07880	gatC	1527811..1528113 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
IM723_RS07885	-	1528253..1528507 (-)	255	WP_065972531.1	glycosyltransferase	-
IM723_RS07890	-	1528520..1528717 (-)	198	WP_231108739.1	glycosyltransferase	-
IM723_RS07895	-	1529045..1530487 (-)	1443	Protein_1511	6-phospho-beta-glucosidase	-
IM723_RS07900	msrA	1530640..1531149 (-)	510	WP_211836858.1	peptide-methionine (S)-S-oxide reductase MsrA	-
IM723_RS07905	-	1531161..1532009 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
IM723_RS07910	-	1532132..1532683 (-)	552	WP_084829819.1	isochorismatase family cysteine hydrolase	-
IM723_RS07915	codY	1532746..1533531 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
IM723_RS07920	-	1533791..1535005 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
IM723_RS07925	-	1535360..1535812 (+)	453	WP_065972535.1	universal stress protein	-
IM723_RS07930	-	1535992..1536563 (+)	572	Protein_1518	IS30 family transposase	-
IM723_RS07935	-	1536635..1536808 (-)	174	WP_014621904.1	hypothetical protein	-
IM723_RS07940	-	1536869..1537243 (-)	375	WP_065972537.1	hypothetical protein	-
IM723_RS07945	pflA	1537455..1538255 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

Download Length: 261 a.a. Molecular weight: 28919.13 Da Isoelectric Point: 4.5802

                                >NTDB_id=437772 IM723_RS07915 WP_002951720.1 1532746..1533531(-) (codY) [Streptococcus thermophilus strain DMST-H2]

MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI

RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH

LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG

MKGTYLKVLNEGIYDKLKEYE

Nucleotide

Download Length: 786 bp

                                >NTDB_id=437772 IM723_RS07915 WP_002951720.1 1532746..1533531(-) (codY) [Streptococcus thermophilus strain DMST-H2]

ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC

ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG

GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA

CGTGGTATCAGTCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA

AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC

GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT

CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA

AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA

TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT

ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

CodY GAF-like domain (CodY)

(3-182)

CodY helix-turn-helix domain (HTH_CodY)

(201-261)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q5M305

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502

Detailed information NTG0437772