Detailed information NTG0436143

Bioinformatically predicted

Overview

• Name: comYH
• Type: Machinery gene
• Locus tag: HFV09_RS00705
• Genome accession: NZ_CP051138
• Coordinates: 109195..110148 (+)
• Length: 317 a.a.
• NCBI ID: WP_021299429.1
• Uniprot ID: A0A660A6K5
• Organism: Streptococcus pyogenes strain 4063-05
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 104195..115148

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HFV09_RS00665	-	105022..105387 (+)	366	WP_002986560.1	DUF1033 family protein	-
HFV09_RS00670	comYA	105480..106418 (+)	939	WP_002987773.1	competence type IV pilus ATPase ComGA	Machinery gene
HFV09_RS00675	comYB	106354..107388 (+)	1035	WP_011054115.1	competence type IV pilus assembly protein ComGB	Machinery gene
HFV09_RS00680	comYC	107390..107716 (+)	327	WP_011528161.1	competence type IV pilus major pilin ComGC	Machinery gene
HFV09_RS00685	comGD	107691..108119 (+)	429	WP_002986548.1	competence type IV pilus minor pilin ComGD	-
HFV09_RS00690	comGE	108076..108360 (+)	285	WP_011528162.1	competence type IV pilus minor pilin ComGE	-
HFV09_RS00695	comYF	108353..108787 (+)	435	WP_002992738.1	competence type IV pilus minor pilin ComGF	Machinery gene
HFV09_RS00700	comGG	108771..109097 (+)	327	WP_010921801.1	competence type IV pilus minor pilin ComGG	-
HFV09_RS00705	comYH	109195..110148 (+)	954	WP_021299429.1	class I SAM-dependent methyltransferase	Machinery gene
HFV09_RS00710	-	110207..111403 (+)	1197	WP_011528164.1	acetate kinase	-
HFV09_RS00715	-	111590..111898 (+)	309	WP_011528165.1	hypothetical protein	-
HFV09_RS00720	proC	111981..112751 (-)	771	WP_002986527.1	pyrroline-5-carboxylate reductase	-
HFV09_RS00725	pepA	112799..113866 (-)	1068	WP_011528166.1	glutamyl aminopeptidase	-
HFV09_RS00730	-	114331..114615 (+)	285	WP_002992749.1	DUF4651 domain-containing protein	-
HFV09_RS00735	-	114612..114929 (+)	318	WP_011528167.1	thioredoxin family protein	-

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 36043.16 Da
• Isoelectric Point: 4.7205

>NTDB_id=436143 HFV09_RS00705 WP_021299429.1 109195..110148(+) (comYH) [Streptococcus pyogenes strain 4063-05]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLVPVNLLTSPQ
SQLLKQWLKDYAQVVTLITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide

• Length: 954 bp

>NTDB_id=436143 HFV09_RS00705 WP_021299429.1 109195..110148(+) (comYH) [Streptococcus pyogenes strain 4063-05]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACG
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAGATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCTAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACCTGAAAAAAGACGGTTTTGCGATTTTTCTGGTACCAGTCAATTTATTGACAAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGACCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

• N-6 DNA Methylase (N6_Mtase) (68-288)

3D structure

• AlphaFold DB: A0A660A6K5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYH	Streptococcus mutans UA159	65.506	99.685	0.653
comYH	Streptococcus mutans UA140	65.19	99.685	0.65