Detailed information NTG0043146

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: Y1U_RS07770
• Genome accession: NC_017927
• Coordinates: 1489555..1490340 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus MN-ZLW-002
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1484555..1495340

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Y1U_RS07740 (Y1U_C1523)	gatC	1484617..1484919 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
Y1U_RS07745	-	1485059..1485313 (-)	255	WP_024010053.1	glycosyl transferase	-
Y1U_RS10520 (Y1U_C1525)	-	1485326..1485535 (-)	210	WP_080998437.1	glycosyltransferase	-
Y1U_RS07750 (Y1U_Cp0052)	-	1485851..1487295 (-)	1445	Protein_1475	6-phospho-beta-glucosidase	-
Y1U_RS07755 (Y1U_C1526)	msrA	1487448..1487957 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
Y1U_RS07760 (Y1U_C1527)	-	1487969..1488817 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
Y1U_RS07765 (Y1U_C1528)	-	1488941..1489492 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
Y1U_RS07770 (Y1U_C1529)	codY	1489555..1490340 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
Y1U_RS07775 (Y1U_C1530)	-	1490600..1491814 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
Y1U_RS07780 (Y1U_C1531)	-	1492169..1492621 (+)	453	WP_002946987.1	universal stress protein	-
Y1U_RS10525	-	1492801..1493372 (+)	572	Protein_1482	IS30 family transposase	-
Y1U_RS11435 (Y1U_C1533)	-	1493444..1493617 (-)	174	WP_014621904.1	hypothetical protein	-
Y1U_RS07790 (Y1U_C1534)	-	1493684..1494052 (-)	369	WP_014621905.1	membrane protein	-
Y1U_RS07795 (Y1U_C1535)	pflA	1494264..1495064 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=43146 Y1U_RS07770 WP_002951720.1 1489555..1490340(-) (codY) [Streptococcus thermophilus MN-ZLW-002]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=43146 Y1U_RS07770 WP_002951720.1 1489555..1490340(-) (codY) [Streptococcus thermophilus MN-ZLW-002]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502