Detailed information NTG0419601

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: IBC03_RS07910
• Genome accession: NZ_CP061025
• Coordinates: 1532285..1533070 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 13496
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1527285..1538070

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IBC03_RS07875 (IBC03_07895)	gatC	1527346..1527648 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
IBC03_RS07880 (IBC03_07900)	-	1527823..1528041 (-)	219	WP_242683841.1	glycosyltransferase	-
IBC03_RS10300	-	1527980..1528144 (-)	165	WP_242681665.1	glycosyltransferase	-
IBC03_RS07890 (IBC03_07910)	-	1528581..1530025 (-)	1445	Protein_1513	6-phospho-beta-glucosidase	-
IBC03_RS07895 (IBC03_07915)	msrA	1530178..1530687 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
IBC03_RS07900 (IBC03_07920)	-	1530699..1531547 (-)	849	Protein_1515	MetQ/NlpA family ABC transporter substrate-binding protein	-
IBC03_RS07905 (IBC03_07925)	-	1531671..1532222 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
IBC03_RS07910 (IBC03_07930)	codY	1532285..1533070 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
IBC03_RS07915 (IBC03_07935)	-	1533330..1534544 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
IBC03_RS07920 (IBC03_07940)	-	1534899..1535351 (+)	453	WP_002946987.1	universal stress protein	-
IBC03_RS07925 (IBC03_07945)	-	1535531..1536102 (+)	572	Protein_1520	IS30 family transposase	-
IBC03_RS07930 (IBC03_07950)	-	1536174..1536347 (-)	174	WP_011681546.1	hypothetical protein	-
IBC03_RS07935 (IBC03_07955)	-	1536408..1536782 (-)	375	WP_011681547.1	membrane protein	-
IBC03_RS07940 (IBC03_07960)	pflA	1536994..1537794 (-)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=419601 IBC03_RS07910 WP_002951720.1 1532285..1533070(-) (codY) [Streptococcus thermophilus strain 13496]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=419601 IBC03_RS07910 WP_002951720.1 1532285..1533070(-) (codY) [Streptococcus thermophilus strain 13496]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502