Detailed information NTG0419196

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: IBB97_RS08140
• Genome accession: NZ_CP061021
• Coordinates: 1571454..1572239 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 24739
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1566454..1577239

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IBB97_RS08105 (IBB97_08120)	gatC	1566515..1566817 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
IBB97_RS08110 (IBB97_08125)	-	1566992..1567210 (-)	219	WP_242683841.1	glycosyltransferase	-
IBB97_RS10550	-	1567149..1567313 (-)	165	WP_242681665.1	glycosyltransferase	-
IBB97_RS08120 (IBB97_08135)	-	1567750..1569194 (-)	1445	Protein_1560	6-phospho-beta-glucosidase	-
IBB97_RS08125 (IBB97_08140)	msrA	1569347..1569856 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
IBB97_RS08130 (IBB97_08145)	-	1569868..1570716 (-)	849	Protein_1562	MetQ/NlpA family ABC transporter substrate-binding protein	-
IBB97_RS08135 (IBB97_08150)	-	1570840..1571391 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
IBB97_RS08140 (IBB97_08155)	codY	1571454..1572239 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
IBB97_RS08145 (IBB97_08160)	-	1572499..1573713 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
IBB97_RS08150 (IBB97_08165)	-	1574068..1574520 (+)	453	WP_002946987.1	universal stress protein	-
IBB97_RS08155 (IBB97_08170)	-	1574700..1575271 (+)	572	Protein_1567	IS30 family transposase	-
IBB97_RS08160 (IBB97_08175)	-	1575343..1575516 (-)	174	WP_011681546.1	hypothetical protein	-
IBB97_RS08165 (IBB97_08180)	-	1575577..1575951 (-)	375	WP_011681547.1	membrane protein	-
IBB97_RS08170 (IBB97_08185)	pflA	1576163..1576963 (-)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=419196 IBB97_RS08140 WP_002951720.1 1571454..1572239(-) (codY) [Streptococcus thermophilus strain 24739]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=419196 IBB97_RS08140 WP_002951720.1 1571454..1572239(-) (codY) [Streptococcus thermophilus strain 24739]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502